Relationship Between The Initial Position Of Embryo Transfer And Pregnancy Outcomes

Objective:Analyze the relationship between the determination of fresh and frozen-thawing cycle embryo transplanted initial location guided by ultrasound and pregnancy outcome. Discuss whether embryo transplanted initial location affects pregnancy outcome in the process of in vitro fertilization and embryo transfer(IVF-ET) and frozen thawed embryo transfer(F-ET).Methods:Collected IVF-ET and F-ET cycles cases in the first hospital of Shanxi Medical University reproductive department from September 2014 to July 2015. In strict accordance with the research object into exclusion standard screening to meet the requirements. Record its general data and treatment information. Finally collected 293 fresh embryo transfer cycles cases and 286 frozen thawed embryo transfer cycles.Measuring all of the patients of the distance from intracervical mouth and gas liquid droplets containing embryo to the fundus of uterus in the process of embryo transfer guided by ultrasound. Calculating the ratio of the distance from embryo to the bottom of the uterus accounts for uterine cavity depth. According to the difference of the distance from embryo to the bottom of the uterus, fresh cycles are divided into four groups of A(<1.0 cm) group, B group(1.1 ~ 1.5 cm), C(1.6 ~ 2.0 cm) group, D(>2.0 cm) group. Also frozen thawed cycles are divided into A2(<1.0 cm), B2(1.1 ~ 1.5 cm), C2(1.6 ~ 2.0 cm),D2(>2.0 cm) group. Respectively analyzing and comparing if there were significant statistical differences among the different distance groups in pregnancy outcome.Meanwhile according to the difference of the ratio of the distance from the embryo to the bottom of the uterus accounts for the depth of the uterine cavity, fresh cycles are divided into four groups of A1(<1/6) group, B1(1/6~1/3) group, C1(1/3~1/2) group, D1(>1/2)group. Also frozen thawed cycles are divided into A3(<1/6) group, B3(1/6~1/3) group, C3(1/3~1/2) group, D3(>1/2) group. Respectively analyzing and comparing if there weresignificant statistical differences among the different ratio groups in pregnancy outcome.Results:The general situation of patients of every group:age, infertility fixed number o f year, body mass index(BMI), the number of F-ET were no statistical difference(P>0.05); The treatment situation of each group:the dosage of Gn, number of retri eved oocytes, high quality embryo number, endometrial thickness of transfer day, E2 values, P values etc were no statistical difference(P>0.05); The clinical pregnanc y rate, embryo implantation rate and abortion rate, ectopic pregnancy rate, early ble eding rate, biochemical pregnancy rate, incidence of placenta previa between the fo ur groups of A and A2(<1.0 cm), B and B2(1.1~1.5 cm), C and C2(1.6~2.0 cm),D and D2(>2.0 cm) had no significance statistical differences(P>0.05);The clinical pregnancy rates and embryo implantation rate of fresh cycle of C1 group(1/3~1/2)is significantly higher than A1(<1/6) and D1(>1/2) group, the difference was statis tically significant(P<0.007). The clinical pregnancy rate of C3 group of frozen tha wed cycle(1/3~1/2) is significantly higher than A3(<1/6) and D3(>1/2) group, thec linical pregnancy rate of group B3(1/6~1/3) is significantly higher than group D3(>1/2), the difference was statistically significant(P<0.007); The embryo implantation rate of C3(1/3~1/2) group is significantly higher than A3(<1/6) and D3(>1/2) grou p,the difference was statistically significant(P<0.007).Conclusions:In the process of embryo transfer, the different of distance from the embryo to the bottom of the uterus does not affect the pregnancy outcome. Due to the influence of the uterine cavity depth, the different of the ratio of the distance from the embryo to the bottom of the uterus account for the depth of the uterine cavity have a certain influence pregnancy outcome. During embryo transfer according to the uterine cavity depth choose the appropriate transfer position can improved the pregnancy rate.