Effect Of Chronic Endometritis Treatment On The Outcome Of Frozen-thawed Embryo Transfer

Objective To investigate the impact of different treatment options and outcomes for chronic endometritis pregnancy outcomes in patients with ≥2 failed transfers for frozen-thawed embryo transfer(FET).MethodsTwo hundred and forty-four patients who received in vitro fertilization-embryo transfer(IVF-ET)/intra-cytoplasmic single sperm injection(ICSI-ET)from January 2017 to October 2021 at the Reproductive Center of the Maternal and Child Health Hospital of Anhui Medical University were selected as the study population.The 244 patients who had failed to undergo in vitro fertilization-embryo transfer(IVF-ET)or intra-cytoplasmic sperm injection-embryo transfer(ICSI-ET)for ≥2 times were divided into the Chronic endometritis(CE)group(141 patients)and the non-CE group(Group A)(103 patients)according to the results of hysteroscopy + endometrial pathology biopsy.Patients in the CE group were reexamined by hysteroscopy + pathology after treatment,and the CE group was divided into CE-cured group(Group B): 127 cases and CE-untreated group(Group C): 14 cases according to the results of the reexamination,and then the patients in the three groups underwent FET again(a total of 452 cycles),of which 233 cycles were in group A,190 cycles in group B and 29 cycles in group C.After comparing the treatment in plans A,B and C pregnancy outcomes of FET.The CE groups were divided into teatment plan 1: 58 cases,teatment plan 2: 47 cases and teatment plan 3: 36 cases according to the different treatment plans,of which 93 cycles were in teatment plan 1,68 cycles in teatment plan 2 and 58 cycles in teatment plan3.The cure rates of CE in teatment plan 1,teatment plan 2 and teatment plan 3 and the pregnancy outcomes of FET cycles after the three treatment plans were compared.ResultsCE was detected in 141(57.8%)of 244 patients with ≥2 failed transfers;in all FET cycles after CE treatment,the clinical pregnancy rate was higher in group B than in groups A and C(51.58%.vs.33.05% and 20.69%),with statistically significant differences(P < 0.05).In all FET cycles after CE treatment,the clinical pregnancy rate in group B was higher than that in groups A and C(51.58%.vs.33.05% and 20.69%),and the difference was statistically significant(P < 0.05);the implantation rate in group B was higher than that in groups A and C(37.27%.vs.25.41% and 15%),and the difference was statistically significant(P < 0.05);the differences in the miscarriage and biochemical pregnancy rates in groups A,B and C were not statistically(P > 0.05).The differences in cure rate,implantation rate,clinical pregnancy rate,biochemical pregnancy rate,and miscarriage rate were not statistically significant(P > 0.05)among treatment plan 1,treatment plan 2,and treatment plan Conclusions1.Treatment of chronic endometritis can effectively improve embryo implantation rates and clinical pregnancy rates in patients with ≥2 transfer failures for freeze-thaw embryo transfer,thereby improving pregnancy outcomes.2.There were no significant differences in CE cure rates and pregnancy outcomes between treatment plans.