The Correlation Study Of CRP，TRX，Adiponectin And IL-6 In Patients With Severe OSAHS

Objective:1. To investigate the severe obstructive sleep apnea hypopnea syndrome(OSAHS), OSAHS patients with oxygen and sulphur also protein(TRX)and C-reactive protein(CRP), interleukin- 6(IL-6), adiponectin(adiponectin) level changes.2. To analyze the role of TRX, CRP, IL-6, and adiponectin levels in the progression of the disease in patients with severe OSAHS.Method:1.Randomly selected in our hospital otolaryngology clinic and respiratory sleep monitoring room visits, by polysomnography detection and diagnosis for severe OSAHS patients 42 cases as experimental group; normal physical examination center of our hospital patients 33 cases as the control group.2.All subjects were measured for height, weight, neck circumference, waist circumference, hip circumference, severe OSAHS by PSG recording AHI, the longest respiratory pause time, lowest nocturnal arterial oxygen saturation and other parameters.3.All subjects were taken early morning fasting blood, centrifugation, extraction supernatant,-80 C refrigerator preservation, using enzyme-linked immunosorbent assay for determination of TRX, CRP, IL-6, adiponectin concentrations.4.Statistical methods were used SPSS13.0 statistical software for analysis,measurement data to show that the two two comparison between the two groups using ANOVA and LSD-t test, P<0.05 differences were statistically significant.Result:1. Comparing with normal control group, compared with severe OSAHS group,the serum levels of TRX, CRP, IL-6, adiponectin levels are reduced, the difference is statistically significant, severe obstructive sleep apnea hypopnea syndrome(OSAHS)and body mass index(BMI), sleep apnea suspended hypopnea index(AHI), the lowest oxygen saturation and serum TRX, CRP, IL-6 levels were positively correlated,and adiponectin level was negatively correlated.2.severe OSAHS combined with hypertension in patients with serum CRP, TRX,IL-6 levels higher than non hypertensive patients, adiponectin levels compared with non hypertensive patients with lower levels.3.The OSAHS group is different from the healthy control group in ESS values,and there was no significant difference between the groups with severe OSAHS group and non hypertension group.Conclusions:Oxidative stress, inflammation, metabolic disorders play an important role in the pathogenesis of OSAHS, and comprehensive evaluation of OSAHS can better evaluate OSAHS.