Research On Serum Adiponectin Levels In Patients With Obstructive Sleep Apnea- Hyponea Syndrome

Objective To study the changes of serum adiponectin levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) and analyse the influential factors. Methods Polysomnography was examined during sleep, and serum adiponectin levels, fasting plasma glucose (FPG), fasting plasma insulin(FINS) were measured in 60 patients with OSAHS and 20 control simple snorers, the OSAHS patients was divided into mild, moderate and severe group based on the apnea-hypopnea index (AHI). Results Serum adiponectin levels in each OSAHS group were significantly lower than those in the control group(P<0.05), FBG and FINS in each OSAHS group were significantly higher than those in the control group(P<0.05).There were also significantly differences among the mild, moderate and severe group with the development of OSAHS(P<0.05). Serum adiponectin levels were significantly negatively correlated to the body mass index(BMI)(r=-0.66, P<0.01), waist hip ratio(WHR)(r=-0.46, P<0.01), AHI(r=-0.61, P<0.01) and duration of less than 90% of SpO₂ (r=-0.36, P<0.01), FPG(r=-0.54, P<0.05), FINS (r=-0.67, P<0.01), but significantly positively correlated to the minimum value of SpO₂(r=0.38, P<0.01). Partial correlate analysis showed that serum adiponectin levels were still significantly negatively correlated to AHI(r=-0.38, P<0.01), and significantly positively correlated to the minimum value of SpO₂ (r=0.23, P<0.05)after the control of BMI ,WHR, FPG. and FINS. Multiple stepwise regression analysis showed that AHI was an independent risk factor leading to the decrease of serum adiponectin levels except FINS and BMI.. Conclusions In patients with OSAHS, serum adiponectin levels were significantly decreased and significantly correlated to the severity of OSAHS, AHI was an independent factor contributing to the decrease of serum adiponectin level.