Study On The Coagulation Status Of Mycoplasma Pneumonia In Children

Objective:To explore the changes of blood coagulation status,which includes some blood components, in patients of mycoplasma pneumoniae pneumonia during the acute phase, so as to discover the change and the characteristic in these patients.Based on the changes of these coagulation indexes,we may evaluate the severity of disease and find the clew for future research.Methods:A retrospective study was performed in 139 patients with MPP hospitalized in Children’s Hospital of Shanxi Province affiliated to Shanxi Medical University,30 patients admitted to this hospital were included as control group,to exclusion of tumor、trauma、thrombosis,et al.All the patients consecutively included between January 1st 2014 and January 1st 2015,and collected vein blood within four hours. This blood,which was sent to laboratory,was measure complete blood count,blood coagulation,D-dimer level.Results:First,between the patients with MPP and control group,there were no statistical differences for age and gender(P>0.05).When the patients with MPP compared with the control group,platelets counts(PLT) and D-dimer level increased(P<0.01), but prothrombin time(PT)、activated partial thromboplastin time(APTT) declined(P<0.01).For mean platelet volume(MPV),there were no statistical differences between two groups.Second,when the patients with mild MPP compared with the severe one, D-dimer levelincreased(P<0.01), but APTT declined(P<0.01).For PLT、 PT and MPV,there were no statistical differences between two groups.Third,when the patients with MPP compared with the control group,abnormal rate of PLT and abnormal rate of D-dimer level increased(P<0.01), but for abnormal rate of PT、abnormal rate of APTT and abnormal rate of MPV,there were no statistical differences between two groups.Forth, when the patients with mild MPP compared with the severe group, abnormal rate of D-dimer level increased(P<0.01), but for abnormal rate of PLT、abnormal rate of PT、abnormal rate of APTT and abnormal rate of MPV,there were no statistical differences between two groups.Conclusion:(1) There were many changes of blood coagulation indexes in MPP patients, which includes platelet activation, activation of the coagulation pathway, fibrinolysis hyperfunction.This suggests that the body was in a hypercoagulable state. In severe MPP,increased D-dimer rather than other indicators, having made a significant contribution towards the judgment of the disease severity.(2) In the MPP patients,the abnormal rate of platelet count(PLT),and D-Dimer(D-D)increased, the difference is statistically significant, suggesting that it may be as the diagnosis basis for hypercoagulable state of Mycoplasma pneumonia. While for D-Dimer,It can be as a important evidence for Severity of mycoplasma pneumonia’s diagnosis.