The Clinical Significance Of HCY,D Dimer And The Blood Oxygen Index In The Elderly Pulmonary Embolism Patients

Objective:Analysis of the role of HCY, D-dimer and blood oxygen index in the diagnosis of pulmonary embolism in elderly patients.And to explore the significance of HCY, D-dimer and blood oxygen index for the prognosis of elderly patients with pulmonary thromboembolism. Improving the diagnostic rate and to judge the prognosis.Methods:A total of 121 cases were collected,who are in the geriatric department of respiration of the Second Affiliated Hospital of Kunming Medical University during March 2014 to December 2015.Which 61 patients were diagnosed of pulmonary embolism (age is from 60 to 92 years old,average age:75.28±8.45years old) who were enrolled in this study,43 males,18 females, and 60 patients without pulmonary embolism (age is from 60 to 94 years old,average age:73.87±8.91years old) were collected,43 males and 17 female. A retrospective analysis method was used in this study.The following indexes of the patients of the two groups were compared:Age, sex, BMI, chronic lung disease, history of heart failure,history of smoking, history of hypertension, HCY and D-dimer, heart rate, systolic blood pressure, oxygen saturation, arterial partial pressure of oxygen,fibrinogen, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, non high density lipoprotein. To explore the value of the combined detection of the above indicators.SPSS17.0 statistical software was used for the statistical analysis of the results.Results:The following indexes of the two groups were compared:Age, sex, BMI, chronic lung disease, history of smoking, history of hypertension, HCY and D-dimer, heart rate, systolic blood pressure, oxygen saturation, arterial partial pressure of oxygen.fibrinogen, total cholesterol, triglyceride. high density lipoprotein, low density lipoprotein, non high density lipoprotein. HCY and D-dimer in pulmonary embolism group obviously higher than control group, the two groups had significant statistical difference (P< 0.05). There was statistically significant difference between the HCY in three groups in the prognosis degree of pulmonary embolism risk, which has low risk group, medium risk group, high risk group (P< 0.05). There was no statistically significant difference compared between the DD in the three groups (P>0.05). HCY was significantly positively correlated with age (P<0.01). By binary classification Logistic regression analysis, the factors influencing PTE occurred is DD(ug/ml) (OR=2.271,.P<0.001). Age, gender, BMI, chronic lung disease, and smoking history, history of high blood pressure, heart rate and systolic blood pressure, oxygen saturation, arterial partial pressure of oxygen,fibrinogen, fibrinogen, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non high-density lipoprotein cholesterol (NHDL-C) in the diseased group compared with control group which has no statistical significance (P> 0.05).Conclusion:We can find that hcy and D-dimer level increased significantly in elderly patients with pulmonary thromboembolism. Homocysteine is a risk factor for pulmonary thromboembolism, and the risk increases with age.In elderly patients with Hcy and DD increasing is need to be careful of pulmonary embolism, and further improve the CT pulmonary artery is conducive to disease diagnosis. In this study, we found that the level of HCY in elderly patients with pulmonary embolism increased with the risk of prognosis.This result remind that HCY levels may influence the prognosis of patients with pulmonary embolism.There is guiding significance of serum homocysteine levels in judgment of the prognosis of elderly patients with pulmonary embolism, and the HCY levels were higher and the prognosis was poor.Homocysteine levels were positively correlated with age and negatively correlated with blood oxygen saturation.The lower the partial pressure of arterial oxygen partial pressure was found in the risk stratification, the greater the risk of prognosis.The patients with severe hypoxia had a higher level of homocysteine, and the prognosis was poor.Therefore, in elderly patients with increased age and increased hypoxia. HCY levels increased, suggesting a poor prognosis.There has no significance of blood lipid in the elderly patients with pulmonary embolism.