| BackgroundDuring the past decade, the incidence and severity of Clostridium difficile infection (CDI) has increased dramatically throughout the world. However, information about C.difficile infection among general healthcare providers is few in developing country, including China.AimTo reveal several clinical risk factors for C.difficile infection in Chinese population.MethodsA retrospective case-control study was conducted among hospitalized patients in a Chinese tertiary care hospital between December 2013 and July 2015. A total of 81 patients who met the inclusion criteria and 162 age/gender/ward/admission period-matched control patients were included in this study. All statistical analyses were performed using the Statistical Package for Social Science (SPSS, Inc., Chicago, USA) version 19.0. A stepwise logistic regression model was used for multivariate analysis. Statistically non-significant variables (P>0.05) were removed from the multivariate analysis. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were presented for the stepwise logistic regression analysis.ResultsMultivariate analysis indicated that gastrointestinal disease (OR,5.504; 95% CI, 2.152-11.868; P <0.001), history of prior hospitalization (OR,2.826; 95% CI, 1.134-6.077; P=0.008), presence of intensive care unit (ICU) stay (OR,3.142; 95% CI, 1.074-9.193; P=0.037), history of surgery (OR,2.517; 95% CI,1.073-5.904; P=0.034), history of long-term care facility stay (OR,15.234; 95% CI,5.346-43.407; P<0.001), antibiotic use (OR,4.345; 95% CI,1.720-10.975; P=0.002), and chemotherapy (OR, 3.073; 95% CI,1.174-8.046; P=0.022) were independently associations with C.difficile infection.ConclusionThis present study had revealed several clinical risk factors for C.difficile infection in Chinese population. These findings will add to understanding of this disease, underscore the importance of early detection and appropriate clinical care to reduce the fatality and lighten the medical economy burden. |
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