| ObjectiveTo adopt a prospective randomized clinical controlled study to observe influence of fire needling Sihua acupoints to toxic and side reaction of breast cancer patients after surgery, who using chemotherapy with Anthracycline-based combinations drug. Both Quality of life and Karnofsky physical condition are in the study. Thereby, find an effective therapeutic method and a pair of effective acupoints lightening toxic and side reaction of chemotherapy and descent of the quality of life and physical condition caused by chemotherapy.Methods60 breast cancer patients with using Anthracycline-based combinations drug for chemotherapy were divided into two groups in simple randomized method. The control group has 30 patients in simple chemotherapy and the treatment group has 30 patients in chemotherapy plus fire needle on SiHua. The chemotherapy with using Anthracycline-based combinations drug, and with the conventional medicine for preventing toxic and side reaction of chemotherapy. As for the fire needle on SiHua, patients with sitting position, after local disinfection of the bilateral Geshu and Danshu points with cotton balls of iodine, a few drops of Wanhua oil was applied on SiHua. Lighting alcohol burner, burn the fire needle below the body of needle about 3cm until it turn into red, then prick the red-hot fire needle quickly and accurately into acupoints 0. lmm by 7 times, and pull out agility. Then use a cotton ball to press the acupoints for a moment, and apply some wanhua oil on the points. Begin fire needling treatment from one day before of the chemotherapy treatment, once a day. A course of treatment is 3 days. On the first day before chemotherapy, the 1st,2nd,7th and 21st day of chemotherapy, anti-cancer drug toxicity assessment classification level, quality of life and Karnofasky score would be evaluated as efficacy indicators. Gastrointestinal discomforts (vomiting, disgusting and appetite) would be scored on the 1st,2nd,7th day of chemotherapy by ESMO recommended criterion for evaluation. All the data was collected into a database and were analyzed by SPSS22.0 statistical software.Compare of the Karnofasky score:Before the treatment, there were no significant differences in Karnofasky score between the two groups P=0.666 (P>0.05). After the treatment, the Karnofasky score of two groups were decreased P=0.00 (P<0.01), the Karnofasky score of treatment group was higher than the control group P=0.018 (P<0.05).Compare of the quality of life score:Before the treatment, there were no significant differences in the quality of life score between the two groups P=0.428 (P>0.05). After the treatment, the quality of life score of both treatment group and control group were decreased P=0.00, (P<0.01). The difference value of QOL before and after treatment of treatment group was higher than the control group P=0.00 (P<0.05).Compare of blood-system impairment (white blood cell) of anti-cancer drug toxicity reaction:Before the treatment, there were no significant differences in the number of white blood cell between the two groups P=0.97 (P>0.05). After the treatment, number of white blood cell of two groups were decreased P=0.00 (P<0.01). The number of white blood cell decreased of treatment group was higher than the control group P=0.00 (P<0.05).Gastrointestinal discomforts-the degree of disgusting and vomiting on the first day after chemotherapy:There were no statistically significant differences in the number of the degree of disgusting and vomiting between the two groups P=0.598 and P=0.577 (P>0.05). The degree of appetite on the 1st day after chemotherapy:The control group with a lower drgree of appetite disgusting than the treatment group P=0.045 (P<0.05).Gastrointestinal discomforts-the degree of disgusting and vomiting on the 2nd and 7th day after chemotherapy:The control group with a higher degree of disgusting and vomiting than the treatment group on these 2 days. There were statistically significant differences in the number of the degree of disgusting and vomiting P=0.049 and P=0.04 (Both P<0.05). The degree of appetite on the 2nd and 7th day after chemotherapy:The control group with a lower degree of appetite disgusting than the treatment group on these 2 days. There were statistically significant differences in the number of the degree of appetite P=0.028 and P=-0.021 (P<0.05).ConelusionThe study show that fire needling on SiHua in using Anthracycline-based combinations drug chemotherapy patients with breast Cancer after surgery can improve the situation of dropping down of Karnofasky score, the quality of life score and the number of WBC. Besides, the treatment can lower the side effects on gastrointestinal discomforts and improve the degree of appetite. |
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