| Objective To explore the role of 18F-FDG PET/CT in pretherapy assessment and posttherapy monitoring of gynecological malignancies.Methods A retrospective analysis of 68 patients with gynecologic tumors undergoing 18F-FDG PET/CT imaging and having complete clinical data and whose follow-up period was not less than 6 months was done, including 24 ones receiving preoperative 18F-FDG PET/CT testing and 44 ones postoperatively. Definite diagnosis was based on tissue pathology and clinical follow-up data.Results (1) For diagnosis of gynecological malignancies with 18F-FDG PET/CT, the positive predictive value was 98.07%, the negative predictive value was 93.75%, the sensitivity was 98.07%, the specificity was 93.75%, and the accuracy was 97.06%; as regards the conventional imaging method, the positive predictive value was 97.44%, the negative predictive value was 51.72%, the sensitivity was 73.08%, the specificity was 93.75%, and the accuracy was 77.94%. Both methods were significantly different in this respect (P＜0.05). (2) Lesions were identified in 11(11/24) patients with gynecologic tumors undergoing preoperative PET/CT testing,1 of which was proven to be false negative by postoperative pathologic examination; lesions were found in 13 (13/24) patients undergoing PET/CT testing before combined treatment; there were 18 positive results and 6 negative ones for the conventional imaging method. The positive predictive value, sensitivity and accuracy of primary lesion diagnosis were 100%VS100%,95.83%VS75% and 95.83%VS75.00%, respectively for PET/CT testing and the conventional imaging method. Both methods were not significantly in this respect (P>0.05). (3) Out of 42 (42/44) patients undergoing standard operation,28 (28/42) showed lesions by PET/CT testing during follow-up, which was confirmed by postoperative pathologic examination or clinical data; 1 (1/42) also showed lesions by PET/CT during follow-up which were proven pathologically to be caused by inflammation; 14 (14/42) had no lesions when reexamined with PET/CT; 2 (2/44) underwent radiochemotherapy without operation and 1 had a relapse and 1 showed no lesions during follow-up. The conventional imaging method identified 20 cases of relapse, one of which was false positive; 22 cases no recurrence,8 cases of false negative. The positive predictive value, negative predictive value, sensitivity and specificity of diagnosis of recurrent or metastatic lesions were 96.55%VS95.23%,100%VS65.22%,100%VS71.43% and 93.75%VS93.75%, respectively for PET/CT testing and the conventional imaging method. Both methods were significantly different in this respect (P<0.05).Conclusion 18F-FDG PET/CT is more accurate than the conventional imaging method in terms of preoperative evaluation and early diagnosis and positioning of postoperative recurrent or metastatic gynecological malignancies, and deserves to be promoted. |
PDF Full Text Request