An Analysis Of The Correlation Relationship Between Diabetic Foot And Nutritional Status

Objective: Diabetes mellitus(DM),which is caused by genetic and environmental factors, is one of the metabolic diseases characterized by hyperglycemia. With the aging of population and the extension of the duration of diabetes, chronic complications of diabetes is increasing.Diabetic foot(DF) is a common and serious complication of diabetes mellitus. One study show,about 15% of diabetic patients will occur diabetic foot ulcers at a certain time of their life. Another show,about 48% of diabetic foot patients underwent amputation during their hospitalization or within 1 year of follow-up required. A part of the patients with diabetic foot ulcers would suffer amputation,leading to huge economic burden of family and society. Therefore,in order to reduce the occurrence of diabetic foot,the risk factors of diabetic foot has become an important issue in today’s society. Glucose and fatty acid are two big essential nutrients of mammals, and the abnormal glucose metabolism leads to the hyperglycemia state for a long time in patients with type 2 diabetes mellitus,thereby increasing the conversion of glucose to fatty acids. Long-term high levels of glucose and fatty acids state will produce "glucose toxicity" and "glucolipotoxicity", so that oxidative stress increases. And the development of diabetic complications and oxidative stress was positively correlated, so more or less there is a certain correlation between the development of diabetic complications and nutritional status. Diabetic foot is one of chronic complications of diabetes, the relationship between diabetic foot and their nutritional status remains to be determined. This study aimed to investigate the relationship between diabetic foot and their nutritional status, in order to prevent the occurrence and development of diabetic foot.Method: Select 169 diabetics as the research objects,who enrolled in District Xin-min of China Japan Union Hospital of Jilin University Endocrinology hospitalized from January 2013 to September 2015. Depending on whether having diabetic foot,they were divided into DF group(69 cases) and NDF group(100 cases).The following factors were included in our study :age, sex, and fasting blood glucose(FBG), lymphocyte count(LC), hemoglobin(HB), total protein(TP), serum albumin(ALB), serum prealbumin(PA), glycerol triester(TG), total cholesterol lipoprotein(TC), low density lipoprotein(LDL-C), high density lipoprotein(HDL-C), blood urea nitrogen(BUN), serum creatinine(SCr) and so on, which are the evaluation of nutritional status related hematologic parameters. The above data are used SPSS Statistics 17.0 software for windows, data expressed as x ± s. In univariate analysis, gender is count data,using chi-square test,and the remaining indicators are measurement data,using t test. After single-factor test, the statistically significant indicators use multivariate Logistic regression analysis to predict the risk factors for diabetic foot, with 95% confidence intervals to represent.Results: Comparing two sets of data, age of the patients with DF are larger than the patients of NDF group,the level of hemoglobin, serum albumin, serum prealbumin, triglycerides, high density lipoprotein were lower than the NDF group, and the level of blood urea nitrogen and serum creatinine were higher than the NDF group.The differences were statistically significant(P <0.05, or P <0.01).However,gender, the level of fasting blood glucose, lymphocyte count, total protein, total cholesterol lipoprotein,and low density lipoprotein had no significant difference(P> 0.05). The indicators were enrolled into multivariate Logistic regression analysis,whose difference was statistically significant in univariate analysis. Statistics showed that the level of serum albumin, hemoglobin, and high density lipoprotein were negatively correlated with the occurrence of diabetic foot,and they were independent protective factors for diabetic foot.However,the level of serum creatinine was positively correlated with the occurrence of diabetic foot,and it was the predictor of diabetic foot.Conclusions: Poor nutritional status, lipid metabolism disorders and kidney damage may be the important factor in the development of diabetic foot.