The Assay Of Serum Level Of CXCL16 In Patients With Coronary Heart Disease And Its Linical Significance

Objective:To explore the function and clinical significance of the levels of serum CXCL16 in patients with coronary heart disease.Methods:We examined 61 patients undergoing coronary angiography:30 patients with acute coronary syndrome and 31 patients with stable angina pectoris. Another 30 patients with normal CAG were served as control group. CXCL16 in peripheral venous blood was measured by sandwich Enzyme-linked immunosorbent assay (ELISA) and C-reactive protein was detected by Immunoturbidimetry. Gensini score was calculated in different groups and GRACE risk score was estimated in the patients with acute coronary syndrome. Pearson correlation analysis was used to compare the level of CXCL16 in different groups, the relation of CXCL16, C-reactive protein and GRACE risk score in the patients with acute coronary syndrome. In all samples,Pearson correlation analysis was used to compare the level of CXCL16 with Gensini score.Results:Expression levels of CXCL16 in peripheral venous blood were significantly higher in acute coronary syndrome group (9.96±6.53ng/ml) than in stable angina pectoris group (6.50±4.53 ng/ml) and Control group (1.70±0.43ng/ml) (P<0.01).The expression levels of CXCL16 in peripheral blood of patients with acute coronary syndrome were positively correlated with C-reactive protein (r= 0.852, p< 0.01) and GRACE risk score (r=0.770, p<0.01). The expression levels of CXCL16 in peripheral blood of all subjects were positively correlated with Gensini score (r=0.904, p<0.01)Conclusions:The levels of serum CXCL16 were significantly increased in patients with acute coronary syndrome and positively correlated with C-reactive protein, Gensini score and GRACE risk score, which would provide important diagnostic information in acute coronary syndrome.