The Clinical Features And Prognosis Of Pregnancy-associated Breast Cancer

Objective:To analyze clinicopathological characteristics of pregnancy-associated breast cancer(PABC)and the matched non-pregnancy-associated breast cancer(No n-PABC).To compare the prognosis difference between the 2 groups.To study the f actors influencing the prognosis of PABC.Methods:41 PABC patients treated in Af filiated Tumor Hospital of Xinjiang Medical University from January 2005 to June2013 were enrolled in this study,each patient in the database was matched with 2Non-PABC patients.The matching criteria were with same age,the treatment time was similar, and the pathological types were infiltrating ductal carcinoma.Results:C ompared with Non-PABC, PABC is much larger, more than T3(P=0.044),high inci dence of lymph node metastasis(P=0.039), the difference was statistically significa nt;the 3-year overall survival rate(OS) pregnancy-associated breast cancer was 70.7%, Non-pregnancy-associated breast cancer was 74.4%, 3 years disease-free surviv al(DFS) pregnancy-associated breast cancer was 63.4%, Non-pregnancy-associated breast cancer was 65.9%. The difference between the two groups had no statistical significance(P > 0.05).Multiple factors analysis showed that TNM stage was an i ndependent prognostic factor in patients with PABC.Conclusion:PABC is easy to d elay in diagnosis, prognosis is poor, to strengthen the prepregnancy and lactation b reast examination, early detection, early diagnosis, early treatment is key to improv e the survival rate of patients with PABC, also needs further analysis of multi cent er clinical data confirmed pregnancy effects on the prognosis and treatment of the fetus.