| Object:This paper through the observation of Jingtengtongfengyin on gouty arthritis of damp heat syndrome in patients with clinical symptoms, signs, laboratory indicator s and other aspects of the preliminary inquiry, Jintengtongfengyin on efficacy, syndro me of dampness heat of gouty arthritis in patients with adverse reactions and safety, fo r the further development and application of the medicine clinical trials data.Methods:From January 2015 to January 2016 in Kunming Hospital of Traditional Chi nese Medicine zhiweibing(Department of rheumatism) outpatients with this clinical s tudy of gouty art-hritis of damp heat accumulation in 60 cases, were randomly divided into two groups randomly, 30 cases in the treatment group, 30 cases in the control gro up. The treatment group was treated by Jintengtongfengyin water decoction, 200m1 p er bag, 1 bags of oral/time, 3 times/day;control group,control group was given Diclofe nac Sodium Sustained Release Capsules(Ying Taiqing, China Medicine University P harmaceutical Co. Ltd., 50 mg * 20) oral, 50mg/time, 2 times/day for 1 week. To obser ve the inflammatory factor score and TCM syndrome pa-tients before and after treatm ent(ESR, CRP), the level of serum uric acid(UA) level.The safety index(ALT, AST,BUN, Scr, blood routine, urine routine) and other laboratory physical and chemical in dicators, through statistical analysis of related data, the evaluation of gold rattan Tong fengyin on efficacy, syndrome of dampness heat of gouty arthritis patients safety and adverse reactions.Results:1.The total efficiency of two groups results: comparison of TCM symptom score:the treatment group 93.3%, control group 76.7%.(P<0.05)2.Treatment grout after treatment of traditional Chinese symptom integral is bette r than of control group.(P<0.05)3.Compare two signs and symptoms: treatment grout improved joint function, bo dy weight difficulties than the control group((P <0.05), two groups of patients in imp roving joint pain, joint involvement, joint swelling, joint, skin temperature, skin joints,tophi no statistical significance(P>0.05).4.Two sets of serum uric acid(UA) were not significantly changed(P>0.05).5.Two groups of patients inflammatory factors(ESR, CRP) than before treatment decreased(P <0.05), and the treatment group improved inflammatory cytokines(ESR, CRP) than the control group(P <0.05).6.Two drugs in patients with ALT, AST, BUN, SCr, blood, urine, stool occult blood and affect routine, ECG was not statistically significant(P> 0.05).Conclusion:1.Jintengtongfengyin and Diclofenac Sodium treat heat Accumulation of gouty a rthritis syndrome are effective, Jintengtongfengyin effective than Diclofenac Sodium.2.Jintengtongfengyin in improving joint function, limb syndrome of dampness he at of gouty arthritis patients trapped heavy is better than Diclofenac Sodium.3.Jintengtongfengyin and Diclofenac Sodium gouty arthritis can improve heat Ac cumulation Syndrome inflammatory factors(ESR, CRP), the treatment group than the control group.4.This issue has not observed the influences of UA that Jintengtongfengyin and Diclofenac Sodium treat the gouty arthritis heat Accumulation patients.5.Jintengtongfengyin and Diclofenac Sodium has no adverse reaction in the proc ess of clinical trials, no serious side effects.The safety index of two groups(blood rout ine, liver function, renal function, urine routine, stool routine and occult blood) were n ot significantly abnormal, the use of this drug is safe.In summary, Jintengtongfengyin has a unique advantage in the treatment of gout y arthritis of damp heat syndrome, the clinical trial is safe and effective, worthy of fur ther promotion and application of prescription. |
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