The Effects Of Estrogen-progestin On Endometrial And Sub-endometrial Blood Flow In Patients After Hysteroscopic Lysis Of Intrauterine Adhesions

Objectives:Estrogen-progestin play a major role in increasing endometrial and sub-endometrial blood flow during the luteal phase. This study was done to compare endometrial and sub-endometrial blood flow parameters during the luteal phase between patients with intrauterine adhensions and healthy examined people and also to evaluate the effects of estrogen-progestin on blood flow parameters in the intrauterine adhensions.Methods:From July 2014 to July 2015, a totle Of 40 women with intrauterine adhensions by hysteroscopy diagnosis were included in this study. They were performed under hysteroscopic lysis. The normal group was choosed 40 women with healthy examined people at the same time, the same age. There were no significant differences in general clinical data(age、BMI) between two groups(P>0.05). Transvaginal two and three-dimensional pulsed color Dopple ultrasound were done on days 21-23 of the cycle to measure endometrial resistance and pulsation indices(RI、PI) and thesub-endometrial vascular, flow and vascular-flow indices (VI、FI、VFI). Estrogen-progestin (Femoston) were administered part of the patients after hysteroscopic lysis of intrauterine adhensions two cycle. The mean, standard deviation and the Student t test were used to analyze datas. The P<0.05 was considered statistically significant.Results:Patients with intrauterine adhensions had significantly higher endometrial resistance and pulsation indices(RI、PI) and lower sub-endometrial vascular, flow and vascular-flow indices(VI、FI、VFI). Estrogen-progestin significantly improved endometrial and sub-endometrial blood flow parameters.Conclusion:Endometrial and sub-endometrial blood flow decreased during the luteal phase in patients with intrauterine adhensions. Estrogen-progestin increased endometrial and sub-endometrial blood flow and was possible of a therapeutic value.