Investigation Of The Occurrence And Related Factors On Anti-Tuberculosis Drug Adverse Reactions In Urumqi

Objective: To understand the occurrence of adverse reactions caused by anti-tuberculosis drugs, and to explore its risk factors in Urumqi. To provide a scientific basis for the early identification and prevention of the occurrence of ADRs. Methods:This study use a cross-sectional study design method, select pulmonary tuberculosis patients who receiving treatment in Xinjiang Urumqi City TB Designated Hospitals from January 2013 to December 2014 as the research object. The patients receiving the liver,kidney and blood routine examination at the end of,0,2,5,6 after starting treatment, and are recorded the occurrence of adverse reactions. Collect and sort out the research object of related information(medical records, medication records, laboratory and ADRs related information). According to the judging standardization of ADRs into the ADRs group and normal group, using the single factor and multiple factors logisistic regression analysis the related factors of ADRs. Results: The overall incidence of ADRs was60.62%. Multiariable Logistic regression showed that compared with the han, uygur,kazak and other ethnic minorities were at lower risk for the occurrence of ADRs;Compared with the referral, tracking, because the clinical symptoms to take the initiative to see a doctor, because the clinical symptoms were recommended were at lower risk for ADRs occurred; Compared with the phase strengthening supervision, the entire management were at lower risk for ADRs;Compared with patients who did not taking the fixed- dosed combination, Taking FDC patients were more likely to happen ADRs.Recurrent patients, The antibody detection of HIV positive patients and patients with history of BCG vaccination, patients with history of liver disease or allergy were more likely to happen ADRs during anti-tuberculosis treatment. Conclusion: In the process of anti-tuberculosis treatment.High risk patients including retreatment patients, history ofliver diseases, history of drug allergy, antibody detection positive for HIV etc. During the intensive period in anti-tuberculosis treatment should closely monitor the liver and kidney function, and add the blood routine examination to the inspection project.