The Clinical Research Of Qingchang Decoction With Etention-Enema For Intestinal Endotoxemia Of Liver Cirrhosis

Objective:To illuminate the efficiency and security of Chinese medicine Qingchang decoction with retention-enema for intestinal endotoxemia of liver cirrhosis patients.Methods:95 endotoxemia of liver cirrhosis patients, endoretention of damp heat, identified by TCM, were randomly divided into test group (32cases), control groupâ‘ (31cases)and control group â‘¡(32cases). Besides the regular therapy (Nucleoside antiviral, protecting the liver, backing the yellow, anti-liver fibrosis, regulating intestinal flora and symptomatic treatment),the test group was given Qingchang decoction with retention-enema, 100mlper day; and the control groupâ‘  was given 5 glactulose per os,3 times per day. This therapy was sustained for 15 days. The clinical symptoms, such as abdominal distension, hypochondriac pain, acratia and somnus, the endotoxin, liver function, cruor function test, before and afterthis clinical treatment were documented. The data was statistical analyzed in comparison.Results:1. Endotoxin was decreased significantly after 15 days cure process, therapy group and control groupâ‘  with P<0.01 and control groupâ‘¡ P<0.05. The therapy group present more efficacious effect than the control groupâ‘  and â‘¡ with P<0.05 and P<0.01, respectively. And the groupâ‘  was better than â‘¡ with P<0.05. After treatment, endotoxin decreased significantly in the treatment group and the control groupâ‘ (P<0.01), control groupâ‘  and control group â‘¡ (P<0.05).The treatment group had better effect on decreasing the level of endotoxin than the control group, the control groupâ‘  was better than the control groupâ‘¡.There was significant difference between the two groups (P<0.05).2. TBIL were reduced after treatment significantly, in therapy group and control groupâ‘  with P<0.01 and in control groupâ‘¡ P<0.05, respectively. Obviously, the Qingchang decoction was more efficacious than treatment in groupâ‘  with P<0.05, in groupâ‘¡ with P<0.01. And the one in groupâ‘  is better than groupâ‘¡ with P<0.05. The ALB in three groups was raised after cure(P<0.05). The PT in three groups was decreased after cure(P<0.01).However no significant disparity was obtained (P>0.05). After treatment, all groups could decrease the TBIL, there was significant in the treatment group and the control groupâ‘ (P<0.01), control groupâ‘  and control group â‘¡ (P<0.05). The treatment group had better effect on decreasing the TBIL than the control group, the control groupâ‘  was better than the control groupâ‘¡. There was significant difference between the two groups (P<0.05).The value of ALB increased in all groups(P<0.05), There was no significant difference between the two groups(P>0.05).The value of PT decreased in all groups (P<0.01), There was no significant difference between the two groups(P>0.05).3. The symptoms in three groups were significant lessened (P<0.01). The treatment in therapy group was significantly efficacious than both groupâ‘  and groupâ‘¡ with P<0.01. That in groupâ‘  was much better than in groupâ‘¡ with P<0.05.3. After treatment, the score of symptoms decreased in all groups(P<0.01),the treatment group got better results, the control groupâ‘  was better than the control group â‘¡. There was significant in in the treatment group and the control groupâ‘ (P<0.01),control groupâ‘  and control groupâ‘¡(P<0.05).Conclusion:Chinese medicine Qingchang decoction by retention-enema can significantly decrease intestinal endotoxemia of liver cirrhosis patients of clearing heat and promoting dampness, improve function of liver and cruor function, alleviate the clinical symptoms with no evident toxic effects. It is an efficient and secure candidate for clinical therapy.