Influence Of Intravesical Prostatic Protrusion And The Pathological Pattern Of Benign Prostatic Hyperplasia On The Effect Of TURP

Part Ⅰ Influence of intravesical prostatic protrusion on the effect ofTURPObjective: To discuss the influence of intravesical prostatic protrusion on the effect of transurethral resection of the prostate.Methods: Relevant data of 130 patients with BPH who underwent TURP in our hospital from 2013.1 to 2014.12 were collected. Patients were divided into significant IPP group and insignificant IPP group according to the value of IPP. The effect was compared based on the amount of bleeding and operation time.Results: The average values of PSA,TPV,IPSS,Qo L,Qmax and PVR before TURP were PSA 5.8±3.9 ng/ml, TPV57.2±13.4ml, IPSS 22.6±4.7, Qo L 4.7±0.9, Qmax 10.0±2.4ml/s, PVR 60.5±55.6ml,respectively. After TURP, these average values were IPSS12.3±5.3, QOL 2.5±0.6, Qmax 16.5±3.7 ml/s and PVR 9.4±6.2ml, respectively 。 The changes of IPSS and Qo L of significant IPP group before and after TURP were much higher than that in insignificant IPP group(P=0.015 and P=0.033), the result reached statistically significant difference. But the changes of Qmax and PVR before and after TURP of 2 groups showed no statistically significant difference. The operation time of significant IPP group was much longer than the control group(P<0.05). However, the amount of bleeding of 2 groups showed no statistically significant difference.Conclusions: IPP significantly affect the operation time and IPSS. IPP can be adopted to predict the treatment effect of TURP. The measure of IPP before TURP could guide clinical treatment.Part Ⅱ Influence of the pathological pattern of benign prostatic hyperplasiaon the effect of TURPObjective: To discuss the influence of the pathological pattern of benign prostatic hyperplasia on the effect of transurethral resection of the prostate.Methods: Pathological specimens of 130 BPH patients obtained by TURP were retrospectively analyzed. Specimens were fixed, embedded, sectioned and observed with microscope in HE staining and immunohistochemical staining to analyze the pathological pattern, and to determine MVD and VEGF. The effect of TURP was evaluated by comparing the amount of bleeding and the operation time.Results: Operation time in patients mainly with glandular and vascular hyperplasia was higher than patients mainly with fibrous and smooth muscle hyperplasia(P<0.01). And the amount of bleeding in patients mainly with vascular hyperplasia was much higher than other patients(P<0.01). In patients with similar size of prostate, MVD and VEGF had positive correlation with amount of bleeding. Patients with different levels of histological inflammation had no correlation with amount of bleeding or operation time(P>0.05).Conclusions: Pathological pattern of benign prostatic hyperplasia had correlation with amount of bleeding and operation time, they can be adopted to predict the treatment effect of TURP.