Expression And Clinical Significance Of The Selenium-binding Protein P In Carcinoma Of The Rectum

Objective:To detect the expression of selenium-binding protein P(SBP) in rectal cancer by immunohistochemistry(IHC), and analysis the relationship between SBP and rectal cancer and its clinical significance. Methods:Surgical specimens of 60 cases of rectal cancer, 40 cases of rectal adenoma and 40 cases of normal rectal tissues proved by pathology were collected from Shanxi Dayi Hospital between June 2013 and May 2014. The expression of SBP in these tissues was tested by IHC SABC method, and the result was evaluated according to the positive rates of cells and staining intensity, R×C unordered contingency table Chi-square test was adopted in comparision among three sample rates(a=0.05), independent samples Chi-square test was adopted in comparision of each two sample rates(a=0.0167), and the fourfold table Chi-square test was adopted to analysis the relationship between SBP and clinical pathologic parameters(a=0.05). Results:The positive rate of SBP in normal tissue,rectal adenoma and rectal cancer was 82.5%(33/40)、70.0%(28/40)、45.0%(27/60). The difference among groups was statistically different(c2=15.680, P<0.001), and the difference between cancer and normal tissue、rectal adenoma was significant(c2=14.063,P<0.001; c2=6.061, P=0.015), The expression of SBP was associated with tumor size、infiltration of serosa(P<0.05), and was not associated with gender、age、lymphatic metastasis、tumor cell differentiation、TNM stage(P>0.05). Conclusions:SBP showed lower expression in rectal cancer, which may play an important role in the occurrence、development of rectal cancer, and then provide a new approach for the treatment of rectal cancer.