Alteration Of Gray, White Matter Volume, Cortical Thickness And Surface Area In The Intermediate Sporadic Parkinson’s Disease From The Han Population Of Chinese Mainland

Objective: Sporadic Parkinson’s disease(s PD) is a complex neurodegenerative disorder, including a series of motor and no motor symptoms which can‘t completely explain by the present theory, and diagnosis mainly based on the clinical symptoms. Detecting brain structural changes from magnetic resonance image(MRI) can find the more possible damaged brain structure related to s PD symptoms and provide more objective evidences for the s PD diagnosis. To this end, we investigated the alteration of volume, thickness, surface and density of gray matter(Cortex) in the intermediate s PD from the Han population of Chinese mainland(HPCM).Method:The cortical volumewas examined using the methods of voxel-based morphometry.The thickness, surface and density were examined after the preproccessusing the methods of CIVET-pipeline.The cortical pattern matches the cortical thickness analyses and cortical morphometry on the three dimensional structural MRI in 67 intermediate s PD patients and 35 match control subjects.We used the adjusted comparisons and multivariate regressions to assess themorphologicalchangesof specific brain regions.Result: s PD showed a significantly shrunk volume, thinned thickness, as well as an enlarged or reduced surface of cortex relative to s PD, all densities were not different between s PD and the control group. The majority of lost hemisphere gray matter was symmetric, the morphometric alteration of gray matter in the left hemisphere was significant, the alteration of many brain regions in the frontal, temporal, parietal, occipital, and limbic lobe, cerebellum, caudate and thalamus cortex was strongly related to the neural dysfunction of this disease, which indicated the deficits of many brain regions, not only the disruption of substantia nigra-striatal loops, involved in the development of s PD, resulted in a series of complex symptoms in the disease.Conclusion: Our data shows that the complex clinical symptoms of s PD is associated with the extensive gray matter atrophy, which involves in the progression of s PD. The alteration of local gray matter in MRI may provide an useful diagnosis evidence for s PD diagnosis.