Clinical Study On The Difference Of Cerebral Cortical Surface Thickness In Patients With High Myopia By FMRI

Myopia is a disease with a high incidence worldwide,while high myopia(HM)refers to a refractive error of at least 6 refractive(D)or axial length >26mm,which has a high incidence among Chinese adolescents and may cause permanent visual damage.Therefore,the study of the mechanism of HM is the basis of scientific prevention and control of myopia,and the study of its neural mechanism has made new breakthroughs in recent years.Objective: In order to clarify the changes of brain anatomical structure in patients with High myopia(HM),and to identify specific brain regions related to MH.Our aim was to use functional Magnetic resonance imaging(MRI)to study the changes of whole brain activity in patients with HM and their relationship with clinical features.Method:A total of 82 patients with HM(HM group)and 57 healthy controls(HC group)were included in this study.All participants were matched for age and sex,and all underwent resting-state functional magnetic resonance imaging(RS-MRI)scans of the whole brain.The cortical surface thickness of the whole brain was measured by VBM,and the changes of Functional connectivity(FC)in the area of local cortical thickness changes were detected.The cortical thickness of HM patients was analyzed using the Computational Anatomy Toolbox(CAT 12)to study the neuroanatomical changes.The clinical characteristics of HM patients were analyzed.Result:Compared with HCs,HM patients showed decreased the cortical surface thickness in the left middle occipital gyrus(MOG),left inferior parietal lobule(IPL),right inferior temporal gyrus(ITG),right precuneus,right primary visual area 1(V1),right superior temporal gyrus(STG),right superior parietal lobule(SPL),right occipital pole,and right the primary motor cortex(M1),and increased in the parietal operculum(OP4).(P < 0.05,FWE-corrected),the mean cortical thickness of right orbitofrontal cortex(OFC),right dorsolateral prefrontal cortex(DLPFC)and right subcallosal cortex showed negatively correlation with clinical variables(axis length(ALM),the average macular thickness(AMT),keratometer(KER),KER1,KER2,the mean KER,the mean macular fovea thickness(MFT),the refractive diopter)in HM patients.Conclusion:Our results showed that the cortical surface thickness of multiple brain regions changed in HM patients,and the main functions of many brain regions included language,touch,hearing,motor sense,etc.,suggesting that the neurobiological changes in HM patients may involve defects in language understanding,touch,and motor sense.This is of great significance to the study of the neural mechanism of HM.