Expression And Significance Of CCR7 And L-selectin In Oral Lichen Planus

Objective To detect the expression of CCR7 and L-selectin in the lesions of oral lichen planus(OLP) and normal oral mucosa(NOM), and observe the correlation of CCR7 and L-selectin in OLP, which will provide the possible theoretical basis for the pathogenesis of oral lichen planus.Methods To collect 30 cases which were diagnosed as oral lichen planus and 30 cases of normal oral mucosa tissues. Using immunohistochemistry to observe the expression of CCR7 and L-selectin protein levels in the tissues, and using SPSS Statistic analysis software to analyze their expression whether there is a difference in two groups.Results1. The test results of CCR7 show that: The positive expression of CCR7 is located in cell membranes, and mainly distributed in the lamina propria. Its positive rate is 90% in OLP, and in normal oral mucosa the positive rate is 40%. The protein expression of CCR7 in the OLP group is higher than that in the normal group. After statistical analysis, the results have significant differences(P <0.05).2. The test results of L-selectin show that: The positive expression of L-selectin is located in cell membranes, and mainly distributed in the lamina propria. Its positive rate is 86.7% in OLP, and in normal oral mucosa the positive rate is 36.7%. The protein expression of L-selectin in the OLP group is higher than that in the normal group. After statistical analysis, the results have significant differences(P <0.05).3. In the group with OLP, the protein expression levels of CCR7 and L-selectin are positively correlated.Conclusions1. The protein expression of CCR7 and L-selectin in the OLP group are both higher than that in the normal group, they are involved in the pathogenesis of OLP.2. CCR7 and L-selectin have correlations in the pathogenesis of OLP, and their mechanism remains to be further research.