The Relationship Between The Platelet Parameters、Thickness Of The Spleen、Coagulation Function And Hepatic Cirrhosis Caused Hemorrhage Of Upper Digestive Tract

Objective The platelet parameters and blood coagulation index changes of hepatic cirrhosis patients, and to explore the value of evaluating liver function and hemorrhage of upper digestive tract risk.Methods Ninety-nine hospitalized patients with hepatic cirrhosis were selectively collected in Ningxia General Hospital affiliated to Ningxia Medical University from June 2014 to January 2015. They were divided into several groups separately according to Child-Pugh and hemorrhage of upper digestive tract. The platelet parameters, platelet count and coagulation function index were surveyed and compared between groups. Results were analyzed with statistics, to contrast that they have or not statistic difference between them.Results Between two groups according to liver cirrhosis upper gastrointestinal hemorrhage, PLT and PCT in the hemorrhage group were lower, and MPV, PDW and PLCR were significantly greater than no hemorrhage group. The thickness of spleen, PLT/spleen thickness and coagulation indicator were significantly different between two groups, and the differences were statistical significant(all P<0.05). In tree different Child-Pugh groups, PLT, PLCR and PT in B and C groups were greater than A group, whereas PCT were lower. MPV, PLT/spleen thickness and FIB were all different in tree groups and differences were statistical significant(all P<0.05). The differences of PDW, the thickness of spleen and APTT were statistical significant between C and A group, whose data were greater(all P<0.05). TT in C group were significant less than A and B(all P<0.05).Conclusion The platelet parameters and blood coagulation were changed in hepatic cirrhosis, and closely related to liver function and risk of upper gastrointestinal hemorrhage.