Correlation And Risk Assessment Of Upper Gastrointestinal Hemorrhage And Intestinal Flora Imbalance In Decompensated Cirrhosis

Objective:Detecting the number of lactobacillus and bifidobacteria in feces of patients with decompensated cirrhosis,analyzing the differences of intestinal flora in patients with or without gastrointestinal bleeding,and exploring the changes of intestinal flora in patients with decompensated cirrhosis and their associated There are changes in the flora after digestive tract bleeding,understand the correlation between upper digestive tract bleeding and intestinal flora,reduce and prevent the occurrence and development of upper gastrointestinal bleeding in the decompensated stage of cirrhosis,and provide ideas for clinical treatment.Methods:A total of 60 patients with decompensated liver cirrhosis who were admitted to the Department of Gastroenterology of the Second People’s Hospital of Gansu Province from December 2018 to August 2019 were collected.According to the presence of upper gastrointestinal bleeding,26 patients will be accompanied for the bleeding group,34 patients without hemorrhage were the non-bleeding group;another 60 healthy people who were selected for physical examination in our hospital were selected as the control group.Analyze the intestinal flora of healthy control group,decompensated cirrhosis group,bleeding group and non-bleeding group,collect fresh feces from patients,extract fecal DNA,and apply real-time fluorescence quantitative PCR method to bifidobacteria and lactic acid Detection of bacilli.Group t-test was used to compare the two groups.One-way analysis of variance was used for comparison between multiple groups.P<0.05 was significant and statistically significant.All data were analyzed using the SPSS 22.0 statistical software package.Results:1.Compared with the healthy control group,the number of lactobacillus and bifidobacteria in the decompensated cirrhosis group decreased significantly,and the difference was statistically significant(P<0.05).2.The number of Bifidobacterium and Lactobacillus in the group with bleeding was lower than that in the group without bleeding,and the difference was statistically significant(P<0.05).Conclusion:The number of bifidobacteria and lactobacillus in feces of patients with decompensated upper gastrointestinal hemorrhage changed and showed a downward trend,indicating that patients with decompensated stage of cirrhosis had more imbalanced intestinal flora after upper gastrointestinal bleeding serious.