Clinical Observation Of The Cycle Treatment With Traditional Chinese Medicine Combined With Metformin In Treatment Of Adolescent Polycystic Ovary Syndrome

Objective: By collecting the clinical data and statistically analyzed, this study is about the observation of clinical curative effect cycle therapy with Chinese Traditional Medicine combined with Metformin in the treatment of kidney deficiency and phlegm stasis type of adolescent polycystic ovarian syndrome(PCOS). Compared with western medicine treatment with Metformin and Diane-35, the two groups were observed in the patients before and after treatment with clinical symptoms and signs, biochemical index, B ultrasound detection and basal body temperature changes. This study was to explore the mechanism and advantage of the treatment about Traditional Chinese Medicine cycle therapy combined with Metformin in the treatment of kidney deficiency and phlegm stasis type of youth period of PCOS. Hope to provide new ideas for clinical research and treatment.Methods: From 2013 March to 2014 May in Wuhan City Hospital of Traditional Chinese Medicine treatment of patients, the study collect the criteria of this study of kidney deficiency and phlegm stasis type of adolescent PCOS of adolescent patients with a total of 62 cases, which were randomly divided into treatment group(The cycle treatment with Traditional Chinese Medicine combined with Metformin) and control group(Metformin and Diane-35). The two groups were observed after treatment of clinical comprehensive therapeutic effect, after treatment of clinical syndrome classification, before and after treatment of quantitative score, Body Mass Index(BMI), Waist Rip Ratio(WRH); detection of two groups before and after treatment of Luteinizing Hormone(LH), the ratio of LH/FSH, Testosterone(T), Fasting Blood Glucose(FPG), Fasting Insulin(FINS), Insulin resistance index(HOMA1-IR), observation B ultrasound detection of ovarian volume and the number of follicle, and the Basal Body Temperature(BBT). And we statistically analyzed the data which were collected, and determined the clinical effect.Results:(1)Compared two groups of clinical syndrome data synthesis effect, there was significant difference(P<0.05), clinical significance. The treatment group the total effective rate was 80.65%, and 61.29% in the control group.(2)The two groups before treatment clinical quantitative integral compared P> 0.05, which was no significant difference and comparable. After treatment,there was statistical significance in prompting difference(P < 0.05); the treatment group was significantly better than the control group.(3) The two groups before treatment, BMI was compared P> 0.05, which was no significant difference and comparable. After treatment, two groups were compared P<0.05, and there was significant difference between the two groups. It was inferred that after treatment of the two groups of BMI could be improved, and the treatment group was significantly better than the control group.(4) The two groups before treatment on LH,LH/FSH, T levels were compared, P values were more than 0.05, no significant difference, comparable. Differences between groups were statistically after treatment(P<0.05);(5) To compared two groups of patients before treatment FPG, FINS, HOMA1-IR, P values were more than 0.05,which were comparable. The differences were statistically after treatment(P<0.05), indicating that after treatment of the two groups of FPG, FINS, HOMA1-IR levels were improved, and the treatment group in improving insulin resistance effect more obvious.(6) The ovarian volume and the number of follicle were compared between the two groups before treatment, which were no significant statistical difference(P>0.05). After treatment, two groups of ovarian volume and the number of follicle were statistically significant difference(P<0.05), suggesting that the two groups after treatment of ovarian volume were decreased and the number of small follicles were cut down. And the effect of the treatment group is better.(7) Compared two groups of patients after BBT treatment, the difference has statistical significance after treatment(P<0.05), two groups were abnormal BBT corrected to some extent, to restore the dual phase temperature.Conclusion: The cycle treatment with Traditional Chinese Medicine combined with Metformin can effectively improve the clinical symptoms and signs of the kidney deficiency and phlegm stasis type of adolescent PCOS. The treatment can be significantly reduced in adolescent PCOS patients with LH, LH/FSH, T, BMI, FPG, FINS, and HOMA1-IR and so on. It can also effectively improve the ovarian volume in B ultrasound and the number of small follicles. And it could be restoring the dual phase BBT in some degree. The cycle treatment with Traditional Chinese Medicine combined with Metformin has better effect treatment on kidney deficiency and phlegm stasis type of adolescent PCOS.