A Retrospective Study Of Chirdren With Isolated Hematuria Treated By Jin- Shui- Qing

Objective:This study aimed at get a comprehensive understanding of children with isolated hematuria treated by jin-shui-qing. By analyzing the short-term effect and its influence factors, onset time, influence on urinaryβ2-MG, long-term effect and security, to investigate the mechanism and provide clinical basis for standardized use of jin-shui-qing. Methods:Retrospectively collect patients with isolated hematuria, of Hubei Provincial Traditional Chinese Medical Hospital during 1998 to 2014,make strict inclusion and exclusion criteria, bring the 67 cases fit the requirements into this study. Collect the general situation, treatment and laboratory examination. The observation time of the short-term effect is use of Jin-shui-Qing for 8 weeks. The observation of onset time including all cases that took effect for the first time after the using of Jin-shui-Qing. Analyzing the data established in the excel table using SPSS 16 statistical software, analyzing the short-term effect and its influence factors, onset time, influence on urinary β2-MG, long-term effect and security. Result: 1. Short-term effectStatistics for 67 cases of the treatment effect, the total effective cases were 60, including 38 cases of clinical cure, 13 cases get obvious curative effect, 9 cases were effective and invalid 7 cases. The total effective rate was 89.55%. 2. Influence factors of short-term effect 2.1 Correlation of efficacy and course of diseaseThere were 25 cases used Jin-shui –qing at the early stage of disease, 23 cases were effective, effective rate was 92.00%. 32 cases used Jin-shui-qing at the mid-term of disease, 28 cases were effective, effective rate was 87.50%.10 cases used Jin-shui-qing at the later stage of disease, 9 cases were effective, effective rate was 90.00%. The early, middle, late three groups in efficiency, there were no significant differences. 2.2 Correlation of efficacy and TCM syndromeThe syndrome of all patients, 42 were damp heat syndrome, and excess heat syndrome occupied 25 cases. 40 cases with damp heat syndrome were effective, with the effective rate of 95.24%; 20 cases of excess heat syndrome were effective, and the effective rate was 80%. Two groups compared, by chi square test, there was significant difference(P < 0.05). 2.3 Correlation of efficacy and drugs combinedAmong the 67 cases, 58 cases with the use of blood activating drugs, 57 cases were effective, 1 was invalid, total effective rate was 98.28%. The efficiency comparison of compatibility with blood activating drugs group and the group of 67 cases in total, there were significant differences, P < 0.05. 3. Onset timeThere were 60 cases took effect within 8 weeks. Within 1 week only 1 case, accounted for 1.49%; 1 week ~2 weeks were 11 cases,accounted for 16.42%; 2 weeks ~4 weeks were 19 cases,accounted for 28.36%; 4 weeks ~8 weeks were 29 cases, accounted for 43.28%.Another 3 cases got effect after 8 weeks of treatment, with the onset time of 12 weeks, 44 weeks and 56 weeks.The onset time was most concentrated in the 2 weeks ~8 weeks. 4. Influence on urinaryβ2-MGIn 67 cases, there were 5 cases with mildly abnormal urinary β2-MG before treatment, and after treatment the results show all normal. 5. Long term follow-up 5.1 Long-term effectThe follow-up time was during 9 months ~10 years, with an average of 34.2 months.After 8 weeks of treatment, among the cured 38 cases, 1 case relapsed, with persistent u-RBC of(+). Among the 13 obvious effect cases, 2 cases the u-RBC reduced to(+). 9 effective cases the u-RBC did not change significantly during the follow-up period. 7 invalid cases, 2 cases the u-RBC negative 3 and 14 months after treatment, 1 case u-RBC counted from(+~4+) down to(+) 11 months after. Another 4 invalid cases u-RBC didn’t change much. At the end of follow-up period, all patients with no u-protein, hypertension and renal insufficiency. 5.2 SecurityDuration of 67 cases using Jin-shui-qing was as follows: a maximum of 1.5 years, the shortest 2 months. Among them, 2 months ~ 3 months were 44 cases, accounted for 65.67%; 3 months ~4 months were 13 cases, accounted for 19.40%; 4 months ~5 months were 5 cases, accounted for 7.46%; 5 months ~ a half year were 2 cases, accounted for 2.99%, a half year~1 year were 2 cases, accounted for 2.99%, 1 year ~ one and a half year was 1 case, accounted for 1.49%.All cases with a good general condition, liver function, blood routine examination during the observation period. Conclusion: 1. Jin-shui-qing can reduce the RBC in the urine of children with IH. 2. The efficacy of Jin-Shui-qing on IH children was associated with TCM syndrome and drugs combined, no significant correlation with disease duration. Effect of damp heat syndrome is better than that of excess heat syndrome, blood activating drugs can enhance the effect significantly. 3. The onset time was most concentrated in the 2 weeks ~8 weeks. 4. Jin-shui-qing can reduce the β2-MG in the urine of children with IH. 5. The long-term results of Jin-shui-qing on children with IH is reliable..6.The security of Jin-shui-qing is assured.