| Objective: To explore the significance of serum S100 B protein concentration in early diagnosis of acute cerebral infarction, to study the relationship with neurologic impairment,to analyse its relationship with the position of cerebral infarction and infarction area, and to understand its relevance with early prognosis of acute cerebral infarction.Methods: In cerebral infarction group,their gender, age, smoking history, drinking history, history of diabetes, hyperlipidemia, the area of infarction, infarction location were recorded.within the group of cerebral infarction,in 48 h after onset of cerebral infarction,to extract venous blood,waiting for the testing of S100 B protein.at the same time,to do a comprehensive examination of the nervous system by doctors of neural Department of internal medicine, and record NIHSS score.After the inspection of head CT or MRI, to record the infarction area and location. The control group, their gender, age, smoking history, drinking history, history of diabetes, hyperlipidemia, were recorded,and to detect their serum S100 B protein concentration. After there months, the cerebral infarction group were followed up, to record their daily life ability evaluation application scale(Barthel index,BI) score. Results:1. cerebral infarction group compared with the control group,their age, gender, smoking history, drinking history, history of hypertension, history of diabetes and triglyceride(TG),had no significantdifference(P>0.05). Low density lipoprotein in cerebral infarction group compared with the control group,cerebral infarction group, the LDL value is greater than the control group(P=0.029).2. Cerebral infarction group compared with the control group, the serum S100 B protein concentration in cerebral infarction group(3742.24 ± 544.21) was higher than that of the control group, S100 B protein concentration(3162.24± 525.64), P < 0.01, the difference has statistical significance.3. Within cerebral infarction group, the number of NIHSS score < 8 group was 21 cases, accounted for 35%, ≥ 8 group was 39 cases, accounted for 65%. < 8 group of serum S100 B protein concentrations(3526.81 ± 528.49) was significantly lower than ≥ 8 group of serum S100 B protein concentrations(3910.91 ±509.73), P<0.01, the difference was significant,it means NIHSS score increased, the serum S100 B protein concentration increased either.4. Within 60 cases of cerebral infarction group, the large area of infarction group was 26 cases, accounting for 43%, the secondary was 21 cases,accounting for 35%, the small area was 13 cases, accounting for 22%. Cerebellar infarction group was 4 cases, accounting for 6%, cortical and subcortical infarction group was 10 cases, accounting for 17%, subcortical infarction group was 33 cases, accounting for 55%, cortical infarction group was 13 cases,accounting for 22%.5. Within Cerebral infarction group, the serum S100 B protein concentration group of small area infarction group, middle area infarction group and the large area infarction were compared with each other, F=27.359, P<0.01, between the two groups the differences were significant. They were compared with each other, P<0.01, the difference was significant, namely the larger of the infarction area is, the higher of the concentration of serum S100 B protein is.6. Within Cerebral infarction group, cortical, subcortical and cortical, subcorticaland cerebellar infarction group were compared for the serum S100 B protein concentration in each group,the variance analysis showed that F=2.197, P>0.05, There was no significant differences between the groups.S100 B protein concentration has no significant correlation with infarct location.7. Within cerebral infarction group,good prognosis group was 37 cases, accounting for 62%, 23 cases of poor prognosis, accounted for 38%. Good prognosis group serum S100 B protein concentration(3503.94 ±515.11) was significantly lower than the poor prognosis group,S100 B protein concentration(4125.56 ± 333.06), P<0.01, the difference was significant, namely in the cerebral infarction group, the higher the serum S100 B protein concentration is,the poorer the prognosis will be.8. In the cerebral infarction group, there is a correlation between NIHSS score and infarct area, by the Pearson correlation analysis, the correlation coefficient R=0.398, P<0.05, that is,the greater the area of infarction is,the higher NIHSS score is, the more serious the neural function defect will be.Conclusion:1.The serum S100 B protein concentration in patients with acute cerebral infarction increases significantly, has a correlation with the degree of neural function defect.2.The greater the area of infarction is,the higher NIHSS score is, the more the serum S100 B protein concentration will be.3.Theie is no significant correlation between serum S100 B protein concentration and cerebral infarction area.4. The serum S100 B protein concentration can predict the early prognosis of patients, the S100 B protein concentration is higher, the prognosis is relatively worse. |
PDF Full Text Request