The Variation And Clinical Significance Of Molecular Markers Of Prethrombotic State In Diabetes With Cerebral Infarction Patients

Objective:The purpose of this study is to investigate the molecular markers of prethrombotic state in patients with diabetes complicated with cerebral infarction.Methods:Case-control study was performed in this study.158 cases were allocated to 3 groups:diabetes complicated with cerebral infarction patients (n=72); simple cerebral infarction patients (n=86), and healthy control (n=60). Automatic blood cell analyzer was used to measure PLT, MPV, PDW and PCT. Coagulation method was used to measure the concentration of plasma FIB. The concentration of the D-D was measured by latex enhanced immune turbidimetry method.Results:1. The levels of MPV, PDW, PCT, FIB and D-D in diabetes complicated with cerebral infarction group and simple cerebral infarction group were higher than those in the control group (P<0.01), and there are significant differences among these three groups. However the number of PLTs did not have significant difference among three groups (P>0.05).2. The levels of MPV, PDW, PCT, FIB and D-D in diabetes complicated with cerebral infarction group was higher than simple cerebral infarction group (P<0.01), and there is significant difference between these two groups. However the number of PLTs between the two groups have no significant difference (P>0.05).Conclusions:Molecular markers (MPV, PDW, PCT, FIB and D-D) of prethrombotic state in patients with diabetes complicated with cerebral infarction group and simple cerebral infarction group were expressed higher than control group. This study provides the clinical evidence for treating the prethrombotic state in patients with diabetes complicated with cerebral infarction.