| Objective: to investigate the correlation among lacunar infarction and indexes, including blood flow rate at blood vessels(such as internal carotid and middle cerebral artery), intima-media thickness, serum homocysteine, fibrinogen, and D-dimmer. Methods: Based on the focus and numbers of head CT and MRI scanning, 120 LCI patients are divided into one-sided single cavity obstruction group(SLI Group, n = 43), one-sided multiple cavity obstruction group(UMLI Group, n = 38), two-sided multiple cavity obstruction group(BMLI Group, n=39), and 60 healthy volunteers were set as control group. Carotid arteries ultrasonic testing and transcranial doppler ultrasound are adopted to test the thickness of intracranial and extracranial vascular and blood flow rate respectively. Meanwhile, some biochemical indicators, such as serum HCY, D-Dimmer, FIB, UA and blood fat, were detected and analyzed in different groups. Results:(1)Carotid duplex ultrasound results show that intima-media thickness of carotid artery of patients in the lacunar infarction group is obviously increased than those of the normal control group(P<0.05).(2)Transcranial doppler ultrasound results show that the rate of middle cerebral artery mild stenosis and regional flood flow velocity increase in the lacunar infarction group is obviously increased when compared with the ordinary control group(P<0.05).(3)No significant correlation was found among blood urea nitrogen(BUN), uric acid(UA), and LDLc, TG, CHOL of various groups.(4)According to the relevant analysis, serum HCY, FIB, D-Dimmer show positive correlation with infarct scope, and all these three testing indexes have statistical significance among various groups(P<0.05). Conclusions: The occurrence of lacunar infarction may be related to arteriosclerosis and blood flow change supplied by major blood vessels. HCY, D-Dimmer and FIB are all independent risk factors for lacunar infarction, which can provide assistance for diagnosis and evaluation of lacunar infarction disease. |
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