Diagnostic Value Of Color Doppler Ultrasonography And Fibro Scan Technique In Primary Biliary Cirrhosis

PART ⅠDiagnostic Value of Color Doppler Ultrasonography in primary biliary cirrhosisObjective: To discuss the diagnostic value of color Doppler ultrasonography in primary biliary cirrhosis(PBC) and its clinical significance.Methods: 42 patients of PBC were enrolled. And 30 healthy volunteers were enrolled as control group(group A). 42 cases of PBC were divided into two groups according to the pathological grades: group B(pathologic stage I and II,15 cases);group C(pathologic stage III and IV, 27 cases). Two-dimensional ultrasonography, color Doppler flow imaging(CDFI) and pulse wave Dopp ler(PW) were used to observe the morphology, the size and the surface of the liver and the biliary ductal wall. And the following parameters were obtained: the diameter, the mean veloc ity and the blood flow volume of the po rtal vein; the diameter, the peak systolic veloc ity, the resistance inde x and the blood flow volume of the hepatic artery; the diameter, the average systolic flow velocity and the blood flow volume of the mid hepa tic vein;the average systolic flow veloc ity, the blood flow volume, t he diameter and the mean veloc ity of splenic vein.Results: The rates of the enlarged left liver, the coarsening of hepatic parenchyma, the hepatic regenerative nodules, the hyperechogenicity of biliary ductal wall, the thickening of gallbladder, ascites, splenomagely and enlargement of peritoeal lympatic nodes: group C > groups A and B(all P <0.05). The diameter of the portal vein, the diameter, the peak systolic veloc ity, the resistance inde x and the diameter of the splenic vein: C group> A and B groups(all P <0.05). The mean veloc ity of the por tal vein, t he diameter, the average systolic flow velocity and the blood flow volume of the mid hepatic vein: C group < A and B groups(all P <0.05).There were no significant difference between A group and B group in a ll parameters(all P>0.05).Conclusion: The injured degree of liver can be evaluated by color Doppler ultrasonography. The ultrasonographic findings of PBC are specific in certain degree. The pa rameters of color Dopp ler are helpful in clinical stage and judgement of thrapeutic effect of PBC. And it can provide important evidences for clinical diagnosis.PARTⅡ Evaluation of Fibrosis of liver of primary biliary cirrhosis with Fibro Scan TechnologyObjective: To discuss the value of Fibro Scan technique in the liver fibrosis of primary biliary cirrhosis(PBC) and its clinical significance.Methods: 42 patients of PBC were enrolled. And 30 healthy volunteers were enrolled as control group(group A). 42 cases of PBC were divided into two groups according to the pathological grades: group B(pathologic stage I、II,15 cases);group C(pathologic stage III、IV,27cases). Fibro Scan was performed to obtain the value of elasticity of the liver of the groups(referred to as FS, unit KPa).Results: The FS value of C group was larger tha n that of group A and group B(all P<0.05), and the FS value of B group was larger than that of A group(all P<0.05).There was the biggest differencethe between C group and A group.Conclusion: Fibro Scans is a non- invasive, quantitative techni que which can evaluate the liver fibrosis of PBC. And it can provide important evide nces for clinical staging and judgement of thrapeutic effect of PBC.