Study On The Clinical Effect And The Change Level On The Inflammatory Factor Of Chinese Decoction For Qingjinhuatan On Host Inflammation In Patients With COPD During Acute Episode Period By Lung Phlegm And Heat Constraint Pattern

Objective:To explore the effect of Chinese Decoction for Qingjinhuatan on host inflammation in patients with chronic obstructive pulmonary disease (COPD) during acute episode period by lung phlegm and heat constraint pattern.Methods:50patients with inflammation of COPD during acute episode period by lung phlegm and heat constraint pattern between40to75years old were collected into the present study. They were randomly divided into the treatment and control group, with25patients in each group. In the clinical trial, patients in two groups were treated by different measures. For patients in the control group, routine treatment by basic medicine was applied. For patients in the treatment group, the Chinese Decoction for Qingjinhuatan by oral intake was supplied in addition to the basic medicine. The treatment course for each group lasted for10days. Furthermore, we statistically analyzed the differences in symptom total credits and levels of inflammatory mediators in blood before and after treatment in two groups. We evaluated the potential effect of the Chinese Decoction for Qingjinhuatan on inflammation in patients with COPD.Results:1) The effective rate of patients between two groups was compared after treatment. In the treatment group, total effective rate was96%, which was higher than that in the control group (84%); and the total effective rate of clinical symptom in the treatment group was significantly higher than that in the control group.2) Both neutrophil and CRP levels in peripheral blood of two groups were decreased, and changes in these parameters in the treatment group were significantly than those in the control group. The differences in two groups were statistically significant (P<0.05).3) There were no significant differences in IL-8, TNF-α and IL-17levels in peripheral blood between two groups prior to treatment. After treatment, IL-8, TNF-α and IL-17levels in peripheral blood of patients in the treatment group were lower than those in controls. The comparison between two groups showed statistically significant difference (P<0.05).Conclusion:Treatment with the Chinese Decoction for Qingjinhuatan can markedly improve the clinical symptoms of patients with COPD during acute episode period, which might be related to the inhibitory effect on the host inflammatory response. Meanwhile, there were no adverse reactions of drugs during the treatment process in this clinical study.