| Objective：Chronic gastritis is a common and frequently-occurring disease in clinic, andabout more than90%of the patients who accept gastroscope because of the disease.Helicobacter pylori （Hp） is the main factor that cause Chronic gastritis. Afterlong-term infection, some of the patients would more possibly get gastric mucosaatrophy, hyperplasia, and cancer. The eradication of Hp becomes one of the key pointsin the treatment of chronic gastritis, it helps gastric mucosa inflammation disappear,and reduce chronic inflammation.Sequential treatment regimen and standard triple therapy are used in thetreatment of Hp-associated gastritis in the research. By observing the early cure effectof Hp eradication in sequential treatment regimen and standard triple therapy,following up the patients with Hp eradication for their situation of gastrointestinaltract symptoms, and analyzing the rate of adverse reactions, in order to provide thebasis of efficient and safe eradication program for clinic.Methodology：The objects are patients who were confirmed chronic gastritis with Hp bygastroscopy, they were divided randomly into two groups: sequential treatmentregimen and standard triple therapy group.150patients belonged to the sequentialtreatment regimen group,20mg Esomeprazole and1g Amoxicillin were given to themfor the first five days, then20mg Esomeprazole,0.5g Clarithromycin and0.2gCeftezole were given for the last five days, each of them were taken twice daily.Another150patients belonged to the standard triple therapy group, who took20mgomeprazole,0.5g Clarithromycin, and1g amoxicillin twice daily for ten days.Four weeks after the treatment, Hp was checked again to observe theeradication effect, and score the gastrointestinal tract symptoms of the patientsseparately in the two groups who were followed up four weeks after the treatment, soas to compare the improvement of the symptoms and the adverse reactions in the two groups in the progress of Hp eradication.Result：1．According to the per-protocol analysis (PP）of the Hp eradication rate, the rateof sequential treatment regimen is82.7%, the rate of standard triple therapy is69.3%,the former one is higher （P＜0.05）.2． In the group of sequential treatment regimen, the total score ofgastrointestinal tract symptoms is19.17before treatment and12.56after four weeksof treatment. The later score is less than the former one（P＜0.001）; in the group ofstandard triple therapy, the total score is19.23before treatment and12.69after fourweeks of treatment, the later score is less than the former one （P＜0.001）.3． Before treatment, the difference of the scores of gastrointestinal tractsymptoms in the two groups has no significance（P＞0.05）；while four weeks aftertreatment, the difference of the scores in the two groups has no significance（P＞0.05）;the score gap between before treatment and after is6.16in sequential treatmentregimen group, while it is6.45in the standard triple therapy group, the difference hasno statistical significance（P＞0.05）; the index of curative effect is0.34and0.34respectively, there is no statistical difference（P＞0.05）.4．The rate of adverse drug reactions for sequential treatment regimen group is11.3%, and the rate of adverse drug reactions for standard triple therapy group is10.0%, the difference is not obvious （P＞0.05）.Conclusion:1. The rate of Hp eradication in sequential treatment regimenis more than80%,which is higher than the rate in standard triple therapy group.2. The tract symptoms were improved obviously by using both of the treatments.3. The rate of adverse drug reactions is similar in both of the treatments.4. For the patients with Bismuth taboo that cannot use Bismuth quadruplescheme,10d sequential treatment regimen can be used for Hp-associated gastritistreatment. To do the research of the effectiveness of sequential treatment regimenfurther, it is essential to do some multicenter, large sample and double-blindrandomized clinical studies. |
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