| Objective:To investigate the expression and significance of Ll-cadherin and E-cadherin in colorectal carcinoma. Besides, we discuss the relationship between these two cadherins and the occurring and metastasis of colorectal carcinoma, so as to guide the clinical diagnosis and treatment.Methods:78colorectal carcinoma patients were enrolled form July2011to December2012general surgery department of our hospital, also56healthy people.Specimens were collected. All the cases did not receive the anti-tumor treatment such as chemoradiotherapy. L1-cadherin and E-cadherin were detected by immunohistochemistry and were analysed the relationship with the the occurring, differentiation, the grade and metastasis of colorectal carcinoma.Results:The abnormal expression of E-cadherin was more obvious and the expression of L1-cadherin was lower (the group of Colon cancer patients were69.2%, and the normal group was92.9%.) in colorectal carcinoma patients than in healthy people,P<0.05.As the grade of differentia-tion became lower, the abnormal expression of E-cadherin significantly increased, and the expression of L1-cadherin significantly reduced, P<0.05.The abnormal expression of E-cadherin and L1-cadherin were significantly related to Dukes stage of colorectal carcinoma, as the stage increasing, the abnormal expression of E-cadherin significantly increased, and the expression of LI-cadherin significantly reduced, P<0.05. Metastasis of colorectal carcinoma was also related to expression of E-cadherin and LI-cadherin, the abnormal expression of E-cadherin was more obvious in metastasis group(77.5%) than in non-metastasis group(39.5%), and the abnormal expression of LI-cadherin was more lower in metastasis group(62.5%) than in non-metastasis group(76.3%), P<0.05.Conclusion:The abnormal expression of E-cadherin and LI-cadherin were significantly relate to the occurring of colorectal carcinoma, abnormal expression can be a referenced criteria of grade malignancy and metastasis. |
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