The Clinical Study On320Detector CT Double-input Perfusion To Estimate The Efficiency Of Chemotherapy For Pulmonary Tuberculosis

Objective Explore the320-slice spiral CT perfusion double entry in thequantitative assessment of the technical feasibility of active pulmonary tuberculosisperfusion levels, comparing different types of blood perfusion pulmonarylesions.Materials and Methods23cases of pulmonary tuberculosis They weredivided into3groups according to morphology(8cases of tuberculoma ball,4cases ofcavitary lesions,11cases of infiltrating lesions) undergoing lung dynamic volume CTscan,and the perfusion parameters of interest area were acquired by the use ofperfusion software for carring out statistical analysis about the solid tuberculosislesions.Results Phthisical perfusion parameters: tuberculoma lesion PF(41.51±10.32)ml min－1(100ml)－1; BF (11.87±5.76) ml min－1(100ml)－1; PI0.72±0.09. PF＞BF (P＜0.001).Infiltrating lesion: PF(82.53±51.57) ml min－1(100ml)－1; BF (40.20±19.06) ml min－1(100ml)－1; PI0.66±0.08. PF＞BF (P＜0.001). Cavitary lesions PF(144.9±47.02) ml min－1(100ml)－1; BF (72.4±25.65) ml min－1(100ml)－1; PI0.65±0.02.PF＞BF (P＜0.001).Conclusions The preliminary studies suggest that tuberculosis lesions receive adual blood supply from lesser and systemic circulation, usually,the formercontributes more. The PF, BF value of three groups have significant statisticalsignificance, cavitary lesion with the most abundant blood supply while tuberculomalesions are hypovascular.Compared the PI value of three groups, there was nosignificant difference. Objective: Explore the use of double-entry320-slice CT perfusionimaging techniques to assess the effect of tuberculosis perfusion parameters to predictshort-term effect of tuberculosis chemotherapy.Materials and Methods: Divided30cases of tuberculosis into three groups (12cases of tuberculosis ball,5cases of cavitarylesions,13cases of infiltrative lesions). Compared the two results of one week prechemotherapy and post chemotherapy with30d CT scan, divided into clinical remissiongroup and non-remission group according to the standard of evaluating the effect. Oneweek before chemotherapy and after chemotherapy14d twice CT perfusion scan,comparing with pre and post chemotherapy relationship changes of early CT perfusionparameters.Results: In30patients there were20cases of remission, and10cases ofnon-remission. In30patients, compared early lesion size pre chemotherapy and postchemotherapy, there were no significant changes: chemotherapy before and afterchemotherapy early CT perfusion parameters in both groups were changed. TBtreatment before remission group PF, BF is57.8±11.42,31.46±5.18, was higher thanthe non-remission group before treatment PF, BF value of29.44±11.19,14.06±4.09,the difference was statistically significant (t=6.23,7.61, P=0.001), remission grouptuberculosis perfusion values before and after treatment there was a significantdifference in perfusion values decline, and no relief after perfusion values tuberculosistreatment group increased BF values before treatment after treatment rose to14.06±4.0936.68±4.41, the difference was statistically significant. PF value is slightlyelevated. though no significant difference. Conclusion: There was no significantdifference in lesion size after chemotherapy. Changes of CT perfusion parameters afterchemotherapy have the predictive values of early chemotherapy response. The highpulmonary blood flow of TB indicates that lesions are relatively sensitive tochemotherapy, early remission rate is high. Perfusion value of pulmonary tuberculosisafter treatment related with early chemotherapy effect, BF value increase suggesttuberculosis progress, prognosis is poor.