Salidroside Antagonizes High Glucose-induce Apoptosis By Recovery Of Autophagy Via Upregulation Of MTOR In H9C2 Cells

Objective Persistent hyperglycemia has myocardial toxicity which could induce apoptosis in myocardial cells. Salidroside is the active component of Herba Rhodiolae(the traditional Chinese medicine) which has ability of anti apoptosis. Our study is to investigate whether salidroside antagonizes high glucose-induce apoptosis by recovery of autophagy, and its mechanism underlying.Methods: The expression of m TOR was detected by Western-blotting. The activations of caspase-3 and BECN1 were measured by ELISA. The cell viability was detected by CCK-8 assay. The expression of LC-3 was measured by immunofluorescence.Results: High glucose induced apoptosis, salidroside antagonized high glucose-induced apoptosis by recovery of autophagy via enhancing m TOR expression. Blocking the pathway of m TOR reversed the protective effect of salidroside in H9C2 cells.Conclusions: Salidroside antagonizes high glucose-induce apoptosis by recovery of autophagy via upregulation of m TOR in H9C2 cells.