| Peptic ulcer is a common disease of the digestive system, longer duration, pathogenesis complex, easy to repeated incidence, severe complications, seriously affecting the patient’s quality of life. Acid-suppression drugs, mucosal protective agents,antispasmodics,etc.can help ease the symptoms of patients with peptic ulcer and promote the ulcer healing. But western medicine treatment has a long course, withdrawal symptoms after easy to repeat and more side effects,more experisive. Traditional Chinese medicine (TCM) in the improvement of clinical symptoms, improve the effect of treatment of patients and reduce the recurrence rate is prominent. It is worth further explore and promotion.But modern traditional Chinese medicine for peptic ulcer in the literature of traditional Chinese medicine research have bigger difference.Now,formulate a unified and effective syndrome type standard for the treatment of pertic ulcer can play an invaluable role.Research purpose:Generalizations gastric and duodenal ulcer demographic information (gender, age, etc.), the relationship between ulcer disease and season, ulcer related risk factors (smoking, alcohol, drugs, etc.), ulcers, and the relationship between Hp infection and ulcer typical clinical symptoms of abdominal pain and TCM syndrome types of peptic ulcer.Discussion the ulcer’s pathogenesis regularity of age, gender, Hp infection and ulcer incidence relation with gender, age.And to explore the type of ulcer sydrome, law of abdominal pain and ulcer of the different types of correlation; Discussion the TCM syndrome distribution of gastric and duodenal ulcer syndromes and the correction of age, and the correlation of different types of ulcer, conclusion the distribution of peptic ulcer using the traditional Chinese medicine asthenic and sthenic syndrome, further explore "Shi ZeYang Ming, Xu Ze Tai Yin" theory, provide a reference for TCM clinical treatment of gastric and duodenal ulcer.Research methods:Using the method of retrospective study analysis the 210 clinical cases’ general information (including gender, age, onset seasons, Hp infection, etc.) which line with inclusion and exclusion criteria, ulcer induced factors,Hp relerant factor,clinical symptoms of abdominal pain, TCM syndrome type and analyze the relationship between each other, establish a database; Using descriptive statistics, chi-square analysis, peptic ulcer’s demographic data, relationship between ulcer disease and season, the relationship between Hp infection and ulcer of gender, age, and the relationship between different syndrome types, analysis the correlation between the symptoms of ulcer pain and the different types of ulcer, and analyze the gastric and duodenal ulcer similarities and differences in the law of syndrome differentiation of TCM syndrome type. At the same time analysis the compound ulcer and gastric ulcer and duodenal ulcer similarities and differences.Research result:1 The general situationIn the study,210 cases of petic ulcer patients, including 49 GU cases,134 DU cases,27 cases of CU, DU:GU:CU=4.96:1.81:1, DU:GU=2.73:1.210 cases have males 150 cases and women 60 cases, male/female=2.5:1, GU male and female ratio is 2.1:1, DU male and female ratio is 2.6:1, CU male and female ratio was 2.9:1, peptic ulcer disease exists obvious difference men and women. Before the age 40 male incidence(36%) was more than female incidence (16.7%); Among 41-60 year-old,the incidence of women (66.7%) was significantly higher than males incidence (47.3%),and there are significant differences between ≤30 and 41-50,51-60;30-40 is significant differences between 41-50,51-60.High stage of peptic ulcer in the study was 51-60 years old. As the growth of the age between 30 to 60 years old,ulcer disease is in constant growth. A decreased incidence of ulcer after 60 years. Complex ulcer offen happens after 50 years.This study,GU’s average age was 52.2±12.7 years, DU’s average age was 45.5 ±12.9years, DU’s average age was higher than in the previous study.2 Cause season of petic ulcer and a variety of predisposing factorsPeptic ulcer disease is related to season:peptic ulcer mainly happens in winter, less happens in the spring; With the decreasing of the temperature at the beginning of autumn, the onset of the number increased gradually. Since the spring of independence, along with the rising of the temperature, the onset of gradually reduce in number. A small peak incidence in summer and summer to consider diet drinks and cold food.79 people smoking in peptic ulcer patients, including 4 women, men and women smoking ratio is 18.75:1; In patients with peptic ulcer 60 people drink alcohol, female only 1 person, proportion of men and women drinking 59:1; Peptic ulcer disease may be associated with drinking and smoking.Peptic ulcer of Hp positive rate was 68.6%, GU positive rate was 58.6%, DU positive rate was 71.6%, CU positive rate is 73.3%; The infection rate of Hp is higher than the general population;Male patients with Hp infection rate was 69.4%, female patients with Hp infection rate was 66.6%; Hp positive rate of men is higher than women, but there was no statistical significance.Liver-stomach disharmony has the highest Hp infection rate,77%.Followed by Spleen-stomach deficiency,Gastric collaterals stasis syndrome,Spleen-stomach dam-heat,Gtomach cardioyin, infection rates were 69%,63%,57% and 50%.Among 51 to 60 years old the Hp infection is relatively higher, accounting for 33.3% of the Hp positive patients, followed by 31-40 years old. Between younger30 years old and 61-70 years old have less Hp infection rate.3 The abdominal pain symptoms of peptic ulcerThis study describes have 179 cases in abdominal pain symptoms, accounting for 85.2%; With irregular pain 99 cases, accounting for 55.3%. Describe a regular pain in only 80 cases, including DU significantly to reduce pain after the main meal, CU-free meal after the pain worsened cases.4 The justification of peptic ulcerThe study found that Liver-stomach disharmony is the most common type, Stomach cardioyin and Gastric collaterals stasis syndrome are the lest common type.Except Liver-stomach disharmony, Spleen-stomach deficiency is more prominent in DU and CU; Spleen-stomach dam-heat is more prominent in GU.Liver-stomach disharmony throughout the ages, the 50-year-old former model mainly to Spleen-stomach deficiency, after 50 years mainly to Spleen-stomach dam-heat, Stomach cardioyin syndrome seen in patients over 40 years old.DU, GU and CU are not significant differce between Liver-stomach disharmony, Stomach cardioyin Gastric collaterals stasis syndrome. In Spleen-stomach dam-heat aspect, GU has significantly higher proportion than DU, CU proportion; In Spleen-stomach dam-heat aspect, DU and CU has significantly higher proportion than cases the proportion of GU. DU and GU, CU and GU have obvious differences.GU’s sthenic syndrome accounts for 73.4% of GU, DU’s sthenic syndrome accounts for 64.2% of DU, CU’s sthenic syndrome 1 accountes for 63.0% of CU. GU has litter more sthenic syndrome, DU has litter more asthenic syndrome, CU and is more similar DU.Conclusion:1 Peptic ulcer disease of male is significantly higher than female, this may be related to men’s eating habits (smoking, drinking) and work pressure.2 Peptic ulcer Hp positive rate is higher than the average the prevalence, Hp may be associated with the onset of ulcer.3 DU and GU in the syndrome is different, GU towards the sthenic syndrome, DU towards the asthenic syndrome. CU similar to DU on syndromes, there are differences between the CU and GU on the syndrome.4 This retrospective study in peptic ulcer, Liver-stomach disharmony is the most common type. In Spleen-stomach dam-heat aspect, GU has significantly higher proportion than DU, CU proportion; In Spleen-stomach dam-heat aspect, DU and CU has significantly higher proportion than cases the proportion of GU. DU and GU, CU and GU have obvious differences.5 The findings accord "Shi ZeYang Ming, Xu Ze Tai Yin" theory, clinical study has some significance, for clinical reference. |
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