Association Of Genetic Polymorphisms Of Q-1, T2 Locus Allele In ADAM33 Gene With Chronic Obstructive Pulmonary Disease In Xinjiang Uygur Population

Objective:To analyze the correlation between the polymorphism of Q-1, T2 locus allele in ADAM33 gene and chronic obstructive pulmonary disease (COPD) in Xinjiang Uygur population.Methods:The genetic polymorphism of Q-land T2 locus allele in ADAM33 gene in 107 Uygur patients with COPD and 140 Uygur healthy volunteers were genotyped by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).Result:(1) Compared to the control group, there were a significant difference in the distributions of the genotype and allele of T2 locus in the COPD subjects (all P<0.05). Compared with the GG genotype, the T2 locus of AG+AA genotypes could dramatically decrease the risk of COPD [the odds ratio OR (95%confidence interval CI) being 0.536(0.293-0.983)]. When compared with the G allele, the A allele of T2 locus was protective for COPD [the odds ratio OR (95%confidence interval CI) being 0.498(0.286-0.868)]. (2) The haplotype H4 (GG), H3 (GA) were associated with COPD significantly (all P<0.05). (3) There was no significant association in the forced vital capacity ratio and the first second of forced expiration ratio among GG, AG+AA the genotypes of the T2 site (all P>0.05) among COPD patients.Conclusion:The correlation between the polymorphism T2 locus allele in ADAM33gene and COPD in Xinjiang Uygur population was observed.