| Objective: To analyze the clinical characteristics of glioma patients and investigate their prognostics among clinical, tumor and treatment factors. To provide factual basis for the patients of glioma in prognosis predicting and treatment program developing.Methods: The clinical data of 545 glioma patients who underwent surgery and were pathologically diagnosed in the first affiliated hospital of Soochow university during the period of January 2007 to December 2012 are retrospectively analyzed. The patients were divided into three groups according different WHO histological grades. The distribution differences of every clinical factor in different groups were analyzed with Kruskal-Wallis method. Survival analysis according histologic grades was performed on 341 patients of glioma with complete follow-up data by Kaplan-Meier analysis. In a univariate analysis, variables associated with OS and PFS were assessed using a log-rank test. Variables with P values of less than 0.1 in a univariate analysis were selected for inclusion in a multivariate analysis using a Cox proportional hazards model. Two-sided P values less than 0.05 were considered significant.Results: A total of 545 patients with pathologically confirmed grade I to IV glioma were enrolled in the study. The distribution of age at diagnosis, preoperative KPS scores, preoperative symptoms, were significantly different between different histological grades. The median OS time of low-grade glioma was not reached and for anaplastic glioma and GBM they were 22 and 14 months, respectively. The median PFS time were 41, 13 and 6 months in patients with low-grade glioma, anaplastic glioma and GBM, respectively. For LGG patients, age at diagnose, preoperative KPS, pathological type, and radiotherapy are significant prognostic factors for PFS; preoperative KPS, pathological type preoperative sizures and radiotherapy are significant prognostic factors for OS. For anaplastic gliomas, age, preoperative KPS, pathological type, tumor diameter and EOR were significant associated with PFS; age, preoperative KPS, pathological type, EOR and adjuvant radiotherapy were significant associated with OS. In GBM patients, age, preoperative KPS, EOR and adjuvant chemotherapy were significant associated with PFS time; at the same time age, preoperative KPS, EOR, adjuvant radiotherapy and adjuvant chemotherapy were significant associated with OS time.Conclusions: 1.The distribution of age at diagnosis, preoperative KPS scores, preoperative symptoms, were significantly different between different histological grades. 2.Age at diagnose, preoperative KPS, pathological type, and radiotherapy are significant prognostic factors of all groups of gliomas. Gross total resection and chemotherapy are predictors for better prognosis in HGG groups and preoperative sizures is related to longer OS time in LGG. |
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