Immunohistochemical Study Of Helicobacter Pylori In Hepatic Tissue Of Patients With Hepatic Cirrhosis And Hepatic Carcinoma

Objective: To discuss helicobacter pylori infection in hepatic tissue of patients with hepatic cirrhosis and hepatic carcinoma, and to explore the relevance between them. Methods:Immumohistochemical staining of helicobacter pylori was operated in hepatic paraffin specimens of patients, and all of them were from pathology department and labrary of the institute of organ transplantation of the armed police general hospital. Five observational groups was setted, including hepatic carcinoma, hepatitis B cirrhosis, hepatitis C cirrhosis, alcoholic hepatic cirrhosis,autoimmune hepatic cirrhosis(including autoimmune hepatitis,primary biliary cirrhosis and primary sclerosing cholangitis). There were 30 cases in each of the group. Thirty cases of hepatic tissue from heathy grafts were as the control group. Findspecimens stained area in six groups, find bacteria area stained by high magnification light microscope in it; stained specimens range and color, and the proportion accounted for staining the bacteria found in the record of the total number of bacteria. Finally, all the statistics cross the Armed Police General Hospital of two deputy chief physician judgment result.Results:(1)In hepatic carcinoma group,helicobacter pylori infection was found in eighteen cases(60%).(2)In hepatitis B cirrhosis and hepatitis C cirrhosis, it was found in one case(3.33%) respectively.(3)No helicobacter pylori infection was found in the rest of the group. Conclusion:(1) Helicobacter pylori was an important pathogenic factor in hepatic carcinoma development.(2)Helicobacter pylori was an pathogenic factor in hepatic cirrhosis of HBV and HCV, Multi-center large samples were need to be researched.(3)Wether helicobacter pylori participating in cirrhosis development, it was not explicit.Multi-center large samples were need to be researched.