Comparation Of Vaginal Flora In Patients Of Spontaneous Abortion, Normal First-trimester Women And Healthy Non-pregnant Women

Objective:To investigate the flora distribution characteristics of vaginal secretions from women with spontaneous abortion(SA group), Normal first-trimester women(FT group) and healthy non-pregnant(NP group) women.Methods:Vaginal secretions was collected from the women attending Perinatal clinic and the Public health center of the 2nd affiliated hospital of Soochow University during January2010 to December 2013 and had a bacterial culture by inspection department. Patients of spontaneous abortion(n=1315), normal first-trimester women(n=908) and healthy non-pregnant women(n=812) was involved in this survey.Results:425 cases of 3233 participants vaginal secretions cultured pathogen, with positive rate13.15%.Among them, bacteria positive rate was 19.96%(302/1513) in SA group,7.93%(72/908) in FT group and 6.28%(51/812) in NP group, which had a significant difference(P <0.05) in the detection rate of three groups. Among the three groups, the detection rate of the kinds of pathogen infection had a statistically significant(P<0.05).The top five of dominant bacteria in SA group is Enterococcus faecalis、Candida albicans、Escherichia coli 、group B streptococcus and Ureaplasma urealyticum;FT group is Ureaplasma urealyticum 、Candida albicans, candida tropicalis、 group B streptococcus and Enterococcus faecalis;NP group is Candida glabrata、Ureaplasma urealyticum、Escherichia coli、gardnerella vaginalis and Candida albicans.Conclusions:1. The positive rate of detection of pathogen in vaginal secretion in patients withspontaneous abortion is significantly higher than the other two groups, Enterococcus faecalis、Escherichia coli 、Candida albicans and group B streptococcus is more obvious.Is abnormal vaginal flora a risk factor for spontaneous abortion or spontaneous abortion results in vaginal flora infection,it still needs further research.2. During pregnancy; the vaginal p H acidified to less than 4.5, body resistance decreased, and the infection of pathogenic bacterium in vagina increased.3. The infection rate of vulvovaginal candidiasis in normal first-trimester women is higher than that in healthy non-pregnant women, while, it is the highest. in patients of spontaneous abortion4. The positive rate of Ureaplasma urealyticum in normal first-trimester women was higher than that in healthy non-pregnant women, however, The positive rate in patients of spontaneous abortion does not increase, showing that Ureaplasma urealyticum has nothing to do with spontaneous abortion.