Effect Of Early Life Exposed To Famine On Adulthood Metabolic Disorder And Serum C-reactive Protein Level

Objective To study the metabolic syndrome components level differences and changing trends in the middle age of people born in famine years, and the effect of different stages of early life exposure to famine on abnormal rate of metabolic syndrome components in their middle age. To study the association between famine exposure and adult inflammatory factor(C-reactive protein) and explore the influences of the famine exposure in early life on adult metabolic disorders and metabolic inflammation state.Methods 3793 subjects who accepted physical examination in hospital health management center in 2013 and were born from 1955 to 1965 were included in our study. According to the birth of years, the subjects were divided into three groups: the early childhood exposed group who born between 1955 and 1957(n=1024), the fetal exposed group who born between 1959 and 1961(n=639) and the control group who born between 1963 and 1965(n=1489). The information included general information, dietary intake, physical activity and laboratory biochemical parameters was collected by face-to-face interview using a questionnaire. A total of 803 questionnaires completed effectively and C-reactive protein(CRP) concentrations were measured in 604 serum samples.Results Based on the hospital physical examination data of early life exposure to famine, study on the relationship between exposure and adult metabolic disorders: Among the three groups, there is a significant difference of height, DBP, TC, HDL-C and LDL-C(P<0.05). In male, the level of BMI, TC, TG, LDL-C had a significance difference(P<0.05). In female, the level of height, DBP, FBG, TG, LDL-C had a significance difference(P<0.05). Among the three groups, the abnormal rate of height, DBP, TC, TG had a significance difference(P<0.05). In male, the abnormal rate of BMI, SBP, TG had a significance difference(P<0.05). In female, the abnormal rate of height, DBP, TC, TG had a significance difference(P<0.05).In questionnaire survey, the level of SBP, TC, hip circumference among the early childhood exposed group, the fetal exposed group and the control group had a significance difference(P<0.05). The level of serum C-reactive protein had a significance difference(P<0.05) among the three groups. Adjustment for age, educational level, smoking, drinking, metabolic equivalent and dietary intake still have the same results.Conclusions Famine exposure in the early stage may influence adult’s metaflammation and metabolic syndrome, especially for the level of height, SBP, TC and HDL. Female who exposed famine during pregnancy had a great effect on FBG, but in the rest of the components of MS between early childhood exposed group and control group difference is more apparent. Genetic phenotypes of key development period may by pregnancy lasted until the early childhood. Early life exposure to famine and adult metaflammation markers linked C- reactive protein, the exposure could affect the inflammatory state in the adult body metabolism, increase the risk of MS. It has a great significance to looking for sensitive inflammation markers for early detection of metabolic syndrome risk and effective preventions.