The Clinical Value Of Ultrasonic Acoustic Structure Quantification In Evaluation Of Fibrosis Degree Of Diffuse Liver Disease

Objectives: 1.To explore the value of Acoustic Structure Quantification in differential diagnosis of diffuse liver disease.2. To investigate the clinical implications of acoustic structure quantification(ASQ) technology in the classification with liver cirrhosis.Methods: 1.Cases were collected from May 2013 to May 2014 in Hunan Province People’s Hospital, including 60 cirrhosis patients, 30 cases of hepatitis C patients, 30 cases of fatty liver. All cases were confirmed by clinical diagnosis; The control group included 30 healthy volunteers.2. The cirrhosis patients 24 h clinically relevant data were collected, The following parameters were observed: disease, the date of imaging and laboratory data of serum bilirubin(mg / d L), serum albumin(mg / d L), prothrombin time prolonged(s). The Child-Pugh classification was calculated according to the Child-Pugh classification standard.3. All 150 patients were examined by ASQ technology, All ASQ relevant parameters were recorded, collected in the instrument specific patterns required ASQ section images, dynamic memory image, and then analyzed the regions of interest image(ROI) by the ASQ technology software, obtained the ASQ analysis related parameters, and finally used the statistical analysis software for statistical analysis.Results: 1. Each group of the three compared with the control group,the differences were statistically significant.2. The ASQ related parameter BR-Ratio of fatty liver is less than the control group, the hepatitis group is higher than the control group,the liver cirrhosis group is higher than in the hepatitis group, and the differences were statistically significant. A cutoff value of BR-Ratio to identy the fatty liver group and the normal group is 0.15 with a sensitivity of 61.5%, a specificity of 75.9%;identify the hepatitis group and the normal group is 0.32 with a sensitivity of 93.1%,a specificity of 84.6 %; identy the hepatitis group and the normal group is 0.57 with a sensitivity of 64.2%,a specificity of 85.4%.3. ASQ results in patients with cirrhosis were significantly higher than control group,With the increasing of Child-Pugh grading of liver cirrhosis, ASQ relevant parameters RB-Ratio will increase. There were significant differences of BR-Ratio among the three groups according to the Child-Pugh classification(group A, B, C).Conclusions: 1.ASQ provides a new non-invasive measurement for liver fibrosis in patients with diffuse liver disease. ASQ has a non-invasive, convenient, objective, etc;ASQ has a sonography-based new method in assessment of liver fibrosis.2.ASQ related parameter BR-Ratio can provide preliminary judgment on the degree of cirrhosis, and it may be a clincal prognostic indicator in the liver function reserve.