Clinical Study On The Curative Effect Of Wen Jing Yang Xue Ointment Recipe Treating Dysmenorrhea(the Type Of Cold Coagulation And Blood Stasis) Caused By Endometriosis

ObjectivesThis paper observes the changes observed in the uterine Endometriosis Dysmenorrhea VAS score, pain degree and TCM syndrome, evaluates the clinical efficacy and safety of The Wen Jing Yang Xue ointment recipe in treating the mild to moderate Dysmenorrhea (the type of cold coagulation and blood stasis) caused by Endometriosis. It can provide a new method for patients with chronic disease, and provide the basis for new drug development.MethodsAccording to the diagnostic standard of Western medicine and Chinese medicine (the type of cold coagulation and blood stasis), we choosed the 106 outpatients, age at 18-50 years old and meet the inclusion criteria, during the January 2012-January 2015 in our hospital. We divided them into three groups:the experimental group is named ointment recipe group, treated with Wen Jing Yang Xue ointment recipe (provided by our hospital preparation room) and started to take ointment recipe from the first day of the first menstrual cycle,15 ml each time,3 times a day, and even last three menstrual cycles. The control group were the gestrinone group amd Chinese medicine group. The gestrinone group take gestrinone 2.5mg, twice a week. The Chinese medicine group take Danggui Sini Decoction. They starte from the first day of the first menstruation, and even last three menstrual cycles. In the course of treatment, we observes the VAS effect, dysmenorrhea effect and TCM syndromes effect sign, and of vas curative effect, the degree of dysmenorrhea effect, TCM syndromes, signs, laboratory examination and auxiliary examination results and adverse reactions of clinical observation, evaluate the effectiveness and safety of drug.Result(1)After the treatment, the degree of VAS score in the ointment recipe group is 2.13±1.48, the gestrinone group is 0.58±1.50, the Chinese medicine group is 2.94±1.82, according to the analysis, the gestrinone group comparing with ointment recipe group, the gestrinone group comparing with the Chinese medicine group, the difference is statistically significant (P<0.05). the gestrinone group reduce the degree of VAS score evidently. The the ointment recipe and the Chinese medicine group, the difference was not statistically significant (P>0.05).(2) After the treatment, the degree of dysmenorrhea score in the ointment recipe group is 4.53±2.55, the gestrinone group is 1.62±2.54, the Chinese medicine group is 6.08±2.52, according to the analysis, the difference is statistically significant (P<0.05).The gestrinone group compare with ointment recipe group and Chinese medicine group, with significant difference (P<0.01).That points out that gestrinone can reduce the dysmenorrhea score.(3) After the treatment, the degree of TCM syndrome in the ointment recipe group is 2.47±1.33, the gestrinone group is 3.54±1.70, the Chinese medicine group is 3.24±1.73, according to the analysis, the ointment recipe group and the Chinese medicine group, the difference is statistically significant (P <0.05). the Chinese medicine group and the ointment recipe group, the Chinese medicine group and the gestrinone group, the difference was not statistically significant (P>0.05).(4)The comparison of the VAS curative effect between three groups, the total effective rate of ointment recipe group was 90.00%, the gestrinone group’s was 92%, the Chinese medicine group’s was 80.00%. The comparison of the degree of dysmenorrhea effect between three groups, the total effective rate of ointment recipe group was 93.33%, the gestrinone group’s was 92.31%, the Chinese medicine group’s was 86.00%. The comparison of the degree of TCM syndrome curative effect between three groups, the total effective rate of ointment recipe group was 10.00%, the gestrinone group’s was 96.15%, the Chinese medicine group’s was 90.00%. the differences were statistically significant(P<0.05).(5)The comparison of the CA125 levels, endometriosis disease cyst size and uterine size between three groups, the difference was not statistically significant (P>0.05).ConclusionThe Wen Jing Yang Xue ointment recipe can treat Dysmenorrhea (the type of cold coagulation and blood stasis) caused by Endometriosis effectively. It is better than gestrinone in improving the TCM syndrome effect. The total effective rates of Wen Jing Yang Xue ointment recipe are better than gestrinone in the degree of dysmenorrhea degree effect (93.33%) and the TCM syndrome effect(100%). The.gestrinone in improving the VAS effect is better than Wen Jing Yang Xue ointment recipe and Danggui Sini Decoction Decoction. And the total effective rate of VAS effect is 92.3%. The gestrinone in improving the drgree of dysmenorrhea effect is better than Wen Jing Yang Xue ointment recipe and Danggui Sini Decoction Decoction obviously. While the Wen Jing Yang Xue ointment recipe is better than Danggui Sini Decoction Decoction. The Wen Jing Yang Xue ointment recipe, without obvious adverse reactions, is worthy of further study and clinical application.