The Clinical And Safe Study Of Juanbi Decoction Accessorial Treatment On The Cold And Dampness Blocking Ankylosing Spondylitis

ObjectiveTo investigate the clinical curative effect and safety of Juanbi decoction accessorial treatment on the cold and dampness blocking ankylosing spondylitis in a prospective randomized controlled clinical trials.Methods50 cases of Cold and dampness blocking type AS patients were randomly divided into experimental group (25 cases) and control group (25 cases), the control group was applied conventional therapy (include nimesulide dispersible tablets, enteric-coated tablets sulfasalazine, methotrexate and folic acid tablets), and the experimental group oral Juanbi decoction on the basis of therapy like the control group, test time for three months. The manifestations and other targets (involve overall back pain, night pain, the patient’s overall assessment (PGA), BASDAI, BASFI, spinal mobility (Schober test, scoliosis test, finger-ground distance, pillow-wall distance, chest expansion), CRP, ESR and et al. And monitor generally vital signs (T, BP, P, R), liver function project (ALT、AST), renal projects (BUN, Cre), blood project (WBC, PLT) and adverse reactions in both groups. After the test, assess efficacy differences between the two groups by ASAS20 and ASAS40, and make safety assessments.ResultsIn the planned 50 patients, the test group and the control group have three cases due to work without the system drugs, affect the efficacy and safety of observation to be off. The control group, one patient withdrew from the study, to be off; the control group, one patient occured severe hair loss after two weeks with oral medicine, can not continue to experiment, to be off. The actual completion of the test in 42 cases,22 cases of the experimental group and control group 20 cases. After three months of treatment, both groups of patients overall back pain, night pain, PGA, BASDAI, duration of morning stiffness was significantly improved compared with before treatment, the difference was statistically significant (P<0.01), the treatment group compared with the control group improved more obvious, the difference was statistically significant (P<0.05). The two groups of patients spinal mobility, CRP, ESR than before treatment have improved to some extent, the difference was statistically significant (P<0.05), no difference between the groups statistically significant (P>0.05). The two groups of pillow-wall distance before and after the test changed little. Three months after treatment, the experimental group ASAS20 proportion reached 91%, ASAS40 reach 73%, the control group were 80% and 40%, the experimental group efficacy better than contol group, the difference was statistically significant (P<0.05). During treatment, the control group, one patient ALT increased after one month, taking Glucurolactone one week and the review of indicators became normal. And one patient taking the first three weeks bloating discomfort, relieve itself, did not affect on continue the test. The test group,Liver and Kidney function, blood test items were normal, no serious adverse reactions occurred.ConclusionThe therapy that Juanbi decoction Combined with western medicine can significantly relieve manifesstations, improve spinal mobility, and effectively reduce CRP, ESR of cold and dampness blocking AS patients. Its efficacy better than conventional treatment, and no significant adverse reactions. In summary, on the cold and dampness blocking AS treatment, combined with taking Juanbi decoction, they show anti-inflammatory analgesic and immunomodulatory function better, and more secure.