Comparison Of Preventive Effects Of Different Dose Of Fentanyl On Acute Postoperative Pain In Patients Undergoing Partial Hepatic Resection

Objective To compare the preventive effects of different dose of fentanyl on acute postoperative pain in patients undergoing partial hepatic resection.Methods Fifty-four patients, aged 20-59 years old, selected for partial hepatic resection were randomly divided into three groups,18 cases in each group:2 ug/kg fentanyl (group A),3.5 ug/kg fentanyl (group B),5 ug/kg fentanyl (group C). Group Ⅰ received intravenous injection of fentanyl 2ug/kg, group Ⅱ received intravenous injection of fentanyl 3.5 ug/kg and group Ⅲ received intravenous injection of fentanyl 5 ug/kg at 30 min before the end of surgery. Spontaneous respiration recovery time, recovery time and extubation time were recorded after operation. Modified OAA/S scores, Ramsay sedation scores as well as Prince-Henry scores at 10 min (T1),30 min (T2),4 h (T3),24 h (T4) after extubation were also recorded. 1h after recovery, the administration additional tramadol analgesics was recorded.Results The recovery time, extubation time in group B and group C were significantly shorter than group A (P<0.05). Modified OAA/S scores at Ti in both group B and group C were significantly higher than group A (P<0.05). Prince-Henry scores at T2 and T3 in group B were significantly lower than group A (P<0.05). Prince-Henry scores at Ti-T3 in group B and group C were significantly lower than group A, while group C were significantly lower than group B (P<0.05). Ramsay sedation scores at Ti and T2 in both group B and group C were significantly higher than group A, while group C were significantly higher than group B (P<0.05). The amount of using tramadol and PCIA consumption which were by 24% in the ward were significantly higher in group A than group B, while group B were significantly higher than group C (P<0.05).Conclusion Compared with received intravenous injection of fentanyl 2ug/kg at 30 min before the end of surgery, both fentanyl 3.5 ug/kg and fentanyl 5 ug/kg improved acute postoperative pain of patients undergoing partial hepatic resection. Fentanyl 5 ug/kg was the best analgesic in the three groups and don’t affect the recovery time and extubation time.