Clinical Research For Biomarkers In Essential Hypertension With Atrial Fibrillation

ObjectiveTo explore the difference of biomarkers between patients with essential hypertension and essential hypertension complicated with atrial fibrillation.MethodsThe 1:1 matching case-control study was designed,120 essential hypertensive patients (63 patients with nonvalvular atrial fibrillation (AF) and 57 patients with normal sinus rhythm)from Lanzhou University Second Hospital, were included in this trial. Basic information, cardiac structure and function, biomarkers (C-reactive Protein, interlukin-6, homocysteine, Renin-angiotensin-aldosterone System, soluble Thrombomodulin, von Willebrand Factor, Vascular Cell Adhesion Molecule-1) of all participants were evaluated. SPSS 19.0 software was used for statistical analysis.ResultsThe basic information:age, gender, body mass index, Blood pressure classification, New York Heart Function Assessment, diabetes mellitus rate and coronary heart disease, indicated no significant difference (P=0.061, P=0.141, P=0.275, P=0.152, P=0.263, P=0.342, P=0.074). The clinical biochemical data:Urea, creatinine had no significant difference (P=0.102, P=0.391). Cholesterol, Triglyceride, Low-density lipoprotein, High-density lipoprotein, Atherogenic plasma index showed no significant difference (P=0.124, P=0.177, P=0.513,P=0.224, P=0.432). There was no significant difference in the Cornell index between the two groups (P=0.209). The anatomical structure of the cardiac and the cardiac systolic function, Left Atrial Diameter between two groups showed had significant difference (P=0.008). Left Ventricular End-Systolic Dimension, Left Ventricular End-Diastolic Dimension showed no significant difference (P=0.339, P=0.886), while ejection fraction indicated significant difference (P=0.043). C-reactive Protein, interlukin-6, homocysteine showed no significant difference (P=0.05, P=0.214, P=0.421). There was no difference between the two groups for Angiotensin â… , Aldosterone, Plasma Renin Activity (P=0.367, P=0.233, P=0.485), while Angiotensin â…¡ showed significant difference (P=0.026). Between the two groups, soluble Thrombomodulin showed significant difference (P=0.002), but von Willebrand Factor, Vascular Cell Adhesion Molecule-1 showed no significant difference (P=0.645, P=0.0.944).ConclusionCompared to essential hypertensive patients with normal sinus rhythm, essential hypertensive patients with nonvalvular AF, Angiotensin II and soluble Thrombomodulin increased significantly, which suggest that these two factors may play roles in pathophysiology of atrial fibrillation.