The Clinical Value Of Combined Detection Of Serum SF、CA125 And CA153 In Breast Cancer

Objective : Using the method of Chemiluminescence immunoassay(CLEIA) to detecte the levels of SF, CA125 and CA153 in breast cancer patients’ serum, and explore their clinical value in diagnosis of breast cancer.Materials and methods1 SampleA total of 156 patients were collected from departments of medical oncology and surgical oncology, Xingtai People’s Hospital from December 2013 to December 2014, including 92 breast cancer cases and 64 cases with benign breast disease. All patients were confirmed by histopathology and cytology diagnosis. Other 40 cases of outpatient healthy physical examination were chosen as healthy control. Serum tumor markers SF, CA125 and CA153 were detected for all observation objects.2 Tumor markers determinationSF, CA125 and CA153 were detected by CLEIA.3 Statistical analysisThe SPSS17.0 software was used for statistical analysis. Methods of representation and examination were based on the distribution of quantitative data. qualitative data were analyzed by nonparametric test of x2 test.α=0.05 was the level of text.Results:1 Mean levels of serum tumor markers in three groupsThe SF level of breast cancer group was significantly higher than benign breast disease group, and benign breast disease group was significantly higher than healthy group, the difference had statistically significant(P<0.05). The CA125 and CA153 levels of breast cancer group were significantly higher than that of benign breast disease group and healthy group(P<0.05), the difference between benign breast disease group and the healthy group had no statistically significant(P>0.05).2 Mean levels of serum tumor markers in different stagesThe levels of SF in different stages had statistically significant(P<0.05), witch meaned stage III> stage II> stage I. The levels of CA125 and CA153 in stage I was lower than stage II and stage III, the difference had statistically significant(P<0.05), and there was no difference between stage II and stage III(P>0.05).3 The sensitivity and specificity of serum tumor markers(compared to benign breast disease group)Among SF, CA125 and CA153, SF had the highest sensitivity and the lowest specificity for breast cancer diagnosis, the specificity of CA153 was the highest, the CA125 was the lowest. The diagnostic value of these three serum tumor markers were estimated by Youden index, CA153 was the highest, 0.5074, and CA125 was the lowest, 0.2867. The sensitivity of combined detection of serum SF, CA125 and CA153 was 78.26%.Conclusions:1 SF, CA125 and CA153 in diagnosis of breast cancer had good application value, and could be used as identification indexes of breast cancer.2 The levels of SF, CA125 and CA153 were positively correlated with the breast cancer stages, the higher the levels of serum tumor markers, the more serious the illness.3 The SF had the highest sensitivity, and the CA153 had the highest specificity. Comprehensive assessment, CA153 in the diagnosis of the breast cancer had the highest value, SF secondly, CA125 was the worst. Combined detection of SF, CA125 and CA1153 could improve the sensitivity of diagnosis of the breast cancer.