Study On Relationship Between Serum Trace Elements, Ferritin And Gestational Diabetes Mellitus

ABSTRACTObjective: The changes of serum trace elements(Fe, Zn, Se, Cr, Cu) and ferritin in pregnant women with gestational diabetes mellitus(24-28 weeks) were observed, To investigate the relationship between serum trace elements(iron, zinc, selenium, chromium, copper), ferritin and gestational diabetes mellitus.Methods: 1 The research object 1.1 The study group(the GDM group): choice in October 2013 to December 2014 in the third hospital of shijiazhuang gestational diabetes(24 to 28 weeks of pregnancy) of 100 cases of pregnant women, and the determination of serum iron, zinc, chromium, copper, selenium and iron content of protein, blood sugar, blood fat(triglycerides, high-density lipoprotein cholesterol(hdl-c), low density lipoprotein), such as hemoglobin levels. 1.1 The control group: choice in October 2013 to December 2014 in the third hospital of shijiazhuang(24 to 28 weeks of pregnancy) of 100 cases of normal pregnant women, the determination of serum iron, zinc, chromium, copper, selenium and iron content of protein, blood sugar, blood fat(triglycerides, high-density lipoprotein cholesterol(hdl-c), low density lipoprotein), such as hemoglobin levels. 1.2 Diagnosis criteria of preeclampsia were as follows: diagnosis standard 75 g OGTT diagnostic criteria: if take sugar and 1, 2 hours after blood sugar levels were 5.1 tendency, the tendency for 10.0 L and 10.0 L tendency/L. Any blood sugar levels to reach or exceed the standards, a diagnosis of GDM. 1.3 Inclusion criteria(1) age 25 to 35 years old, and gestational age 24 to 28 weeks.(1) age 25 to 35 years old, and gestational age 24 to 28 weeks.(2) Gestational diabetes diagnosis standards(3) No lack of nutrition and metabolic disorders, recently is not taking any trace elements.(4) not intentional, such as lung, liver, kidney disease and psychiatric patients.(5) to participate in the study voluntarily. 2 Sample collecting:blood preparation collecting: All subjects were fasted overnight after 12 hours on the next morning, 7:00-9:00extraction from elbow vein blood 5 ml, 2 ml, respectively the different blood sampling, processing. 3 The experimental method:Determination of trace elements(Fe, Zn, Cu, Se, Cr): atomic absorption spectrophotometry, Ferritin(SF): electrochemical method High density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C): direct method, Triglyceride(TG) GPO-PAP enzyme method,Fasting blood glucose(FPG) and services including the sugar 1, 2 hours afterthe blood sugar: glucose oxidase method,Hemoglobin(HB): the resistance method.Results:1 diabetes group of FPG, 1 hour and blood sugar, blood sugar 2 hours, Fe,SF, TG, LDL- C, and Cu is significantly higher than the control group, the difference was statistically significant(P < 0.01), SBP is higher than the control group, the difference was statistically significant(P < 0.05), zinc, Se, Cr, significantly lower than the control group, the difference was statistically significant(P < 0.01), HDL- C lower than the control group, the difference was statistically significant(P < 0.05), Two groups of gestational age, height, weight, BMI, DBP, HB level difference has no statistical significance(P > 0.05) SF and FPG.2 SF and FPG, 1 hour blood sugar, blood sugar 2 hours, LDL- C, TG, Fe, Cu has significant positive correlation(P < 0.01), and HDL- C, Se, Cr were significantly negative correlation(P < 0.01), and gestational age, height, weight, BMI, SBP, DBP, HB, zinc no correlation(P > 0.05).3 FPG and trace elements have a correlation. 1 hour blood glucose and Se, Cr, Fe, Cu correlated; 2 hours glucose and Fe, Se, Cr correlated.4 1 hour blood glucose and Se, Cr showed a significant negative correlation(P <0.01), and Fe, Cu was positively correlated with P <0.05.5 2 hours glucose and Fe was a significant positive correlation P <0.01, and Se showed a significant negative correlation P <0.01, and Cr was positively correlated with P <0.05.Conclusions:1 Gestational diabetes mellitus patients serum ferritin were significantly higher than normal pregnant women, ferritin increased with the second trimester gestational diabetes have certain relevance, ferritin increasedfor the prediction of the second trimester gestational diabetes has clinical significance.2 The results of gestational diabetes pregnant women serum Cu, Se, Cr,Zn in pregnancy are consistent with the literature, there are still some disputes on serum iron.3 Fasting plasma glucose and trace elements have a correlation. 1 hours of blood glucose and Se, Cr, Fe, Cu has a correlation, 2 hours blood glucose Se, Cr, Fe have a correlation. The disorder of glucose metabolism and trace elements are closely related.4 Serum ferritin and blood glucose, blood lipid, trace elements(Fe, Cu, Se,Cr) there is a correlation, that gestational diabetes mellitus and trace elements, lipid metabolism and other relevant, timely monitoring has certain significance for clinical prevention and treatment, blood lipidchanges of trace elements in GDM.5 The amount of hemoglobin of two groups have no significant difference,which may be related with the selection of gestational age.6 Pregnant women with gestational diabetes mellitus systolic blood pressure was significantly higher than that of the control group, may beferritin indirectly through insulin resistance caused by the elevated systolic blood pressure.