Noninvasive Diagnostic Value Of Forns Index For Liver Fibrosis In Chronic Hepatitis B Virus Infection Patients

ObjectivesThe aim of this study was to explore the diagnostic value of Forns index for liver fibrosis in the patients with chronic hepatitis B(ALT less than five times the upper limit of normal).MethodsThe liver fibrosis severity of 361 CHB patients(ALT less than five times the upper limit of normal)were detected by liver biopsy and the routine laboratory indicators, such as ALT,HBV DNA et al, were examined to calculate the Forns index with the formula. The diagnostic values of Forns index in the significant fibrosis, severe fibrosis and cirrhosis was assessed by using receive operating characteristic curves and using area under the receive operating characteristic curve analysis.Result1. With the severity of liver fibrosis, the patient’s ALB, HBV DNA, cholesterol and PLT decreased with fibrosis aggravation,and the age, GGT, GLB, AST, Forns index gradually increased, which had significant differences between the S1-S4 groups, P<0.05.2. The Spearman rank correlation analysis showed that Forns index and liver fibrosis stage was significantly positive correlation, r=0.451, P<0.001.3. The cutoff value of Forns index is 4.873 for significant liver fibrosis with sensitivity of 68.7% and specificity of 70.3%. The cutoff value of Forns is 5.432 for severe liver fibrosis with sensitivity of 70.2% and specificity of 71.8%. The cutoff value of Forns is 6.289 for cirrhosis with sensitivity of 76.7% and specificity of 81.1%.ConclusionThe Forns index was a simple and effective noninvasive model to predict the severity of liver fibrosis in patients with chronic hepatitis B(CHB). It can make the most of the patients with chronic HBV infection to avoid liver biopsy.