Based On The Literature Review Of Detoxification And Pharmacological Research Ideas To Explore And The Experimental Study Of Detoxicating “Smoke Detoxification” And “Food Poisoning” Of YaJieShaBa

Objective:(1)To investigate the use of modern methods of pharmacology research ideas and methods and to evaluate the effectiveness of Dai medical antidote on the basis of literature research, which provided reference for the national medicine pharmacology experimental research in the future.(2)To investigate the role of delivering “food detoxification” and “tobacco toxin”of Ya Jie Sha Ba with the method of the experiment of pharmacology.Methods:(1)Carding Western medicine, Chinese medicine, detoxification theory of Chinese main minority medicine and representatives of antidotes, analyzing the similarities and differences on the "poison" understanding through literature review and comparison of methods.(2)Established hyperlipemia mice model with the method of intraperitoneal injection of egg yolk emulsion, copied mice model of abnormal glucose tolerance with using the method of tail vein injection of alloxan, copied with allergy with egg protein in mice model, investigated the influence of the appropriate model of blood lipids,blood glucose, intensity of the same passive skin allergy reaction and serum Ig E level of Ya Jie Sha Ba.(3)By intraperitoneal injection of nicotine-induced mice death of acute poisoning method to study pre-given “Ya Jie Sha Ba” whether or was protective effect of acutenicotine poisoning death in mice.Results:(1)Presented experimental research ideas and eight entry points of detoxification methods to evaluate the effectiveness of Dai antidote through literature analysis.(2)Reduce serum TC and TG values in hyperlipidemia mice model, it had no obvious influence on glucose tolerance of normal mice, just lowered blood sugar of abnormal glucose tolerance in mice and there were no statistically significant difference(P>0.05), reduced strength with OVA-induced passive cutaneous anaphylaxis and serum Ig E levels of Ya Jie Sha Ba.(3)Pretreatment with “Ya Jie Sha Ba” intraperitoneal injection of nicotine poisoning caused by acute mortality in mice and compared with control group, it had no effect.Conclusions:(1)The Dai medicine according to our understanding of Ya Jie theory by using specific toxins for detoxification and the detoxification of nonspecific toxins for two ideas, conducted pharmacology experimental study from 8 entry point, which were feasible.(2)Caused acute mouse model of hyperlipidemia by egg yolk emulsion,Ya Jie Sha Ba(3.51g/kg) allowed the model to reduce TG mice and(0.39g/kg) could make model TC decrease in mice, suggesting that it could solve high-fat induced “food poisoning”, but the high sugar caused by “food poison” was not obvious.(3)Ya Jie Sha Ba(3.51g/kg) could reduce ovalbumin-induced the same kind of OD values of passive cutaneous anaphylaxis in mice and serum Ig E. Suggesting that it had anti-allergic effects.