The Clinicopathological Features And The Treatment Analysis Of 65 Cases Of Triple-Negative Breast Cancer

Objective:To reveal the clinicopathological features of triple-negative breast cancer(TNBC) patients and discuss the method to improving their disease-free survival(DFS) and overall survival(OS).Methods:We retrospectively analysed the treatment, clinicopathological features and prognosis of 65 patients belongs to TNBC who operated on at the First Affiliated Hospital of Guangxi Medical University from January 2010 to January 2014. to follow up disease recurrence and metastasis, and breast cancer related deaths.Results:The 65 TNBC patients in this group accounted for the breast cancer in the same period was 12.7%(65/512), patients were from 25 to 70 years old, with average age of 46.3 years old. Tumor maximum diameter were from1.0 to 7.0 cm, with average 3.5 cm diameter. Axillary lymph node metastasis rate was 43.1%(28/65).There are 54 cases (83.1%) of patients with infiltrating ductal carcinoma,3 cases (4.6%) with intraductal carcinoma, and 8 cases (12.3%)with other types, including 2 cases of organic carcinoma,1 case of medullary carcinoma,4 cases of papillary carcinoma, and 1 caseof clear cell carcinoma. Histologic classification:grade â…  level 2 cases (3.1%), grade â…¡ 44 cases (67.7%), grade â…¢ 19 cases (29.2%).Clinical staging (TNM):I, 15.4%(10/65), â…¡,56.9%(37/65), â…¢,27.7%(18/65).45 cases of patient were modified radical mastectomy,12 cases were breast conservative therapy, simple mastectomy plus axillary sentinel lymph node biopsy (SLNB) 8 cases.Accept systemic chemotherapy in 62 cases, including platinum and paclitaxel combination neoadjuvant chemotherapy was 14.5%(9/62), mainly anthracycline-based or with yew combination adjuvant chemotherapy was 82.3%(51/62), to the FEC combined adjuvant chemotherapy was 3.2% (2/62).Postoperative follow-up of 12 months-40 months, mean follow-up of 22.7 months.3 cases of patient were postoperative chest wall recurrence, and 1 person were contralateral breast recurrence, recurrent focal or contralateral breast resection and second-line chemotherapy.Postoperative pulmonary metastasis in 2 cases,1 case that have spread to the liver, bone, brain, etc.4 cases were multiple organ metastasis.All of the patients were treated for the second-line chemotherapy control condition.4 cases of patient died because of the breast cancer,Conclusion:The clinicopathological features of triple-negative breast cancer patients tumor is bigger than others, axillary lymph node metastasis rate is high, clinical stage was later, most of them were with infiltrating ductal carcinoma,and Ki-67 high protein expression, TNBC were a invasive malignant tumor. Patients with TNBC axillary lymph node metastasis, were significantly correlated with pathological tissue type and prognosis.TNBC distant organ metastasis after operation risk is high, and the time early, prognosis is poor.Chemotherapy is the only choice of adjuvant systemic treatment, to further increase the proportion of patients with TNBC accept new adjuvant chemotherapy, by improving the pCR, the new adjuvant chemotherapy is the hope. Improve the level of TNBC treatment.